The relationship between oligodendrocyte loss in the juvenile period and the onset of schizophrenia

• Project/Area Number: 23791348
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Tottori University
• Principal Investigator: YAMACHI Takahira 鳥取大学, 医学部, 助教 (20550817)
• Research Collaborator: IKAWA Daisuke 奈良県立医科大学, 医学部, 大学院生 ; HIROTA Naoya 奈良県立医科大学, 医学部, 大学院生
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 統合失調症 / Olig2

Research Abstract

We hypothesized that oligodendrocyte loss in the juvenile period may influence the onset of schizophrenia, and we focused on the function of Olig2, play an important role in the differentiation of oligodendrocyte. To test the hypothesis, we used double transgenic mice, which can reduce the expression of Olig2 in the juvenile period. The results were that there have not significant differences in our experimental status. We thought that the double transgenic mice were not performed sufficient recombination in our experimental status

Research Products

• [Remarks] ホームページ等 鳥取大学(新規に作成中)
  • URL: http://neuropsychiatry.med.tottori-u.ac.jp/
• [Remarks] 奈良県立医科大学
  • URL: http://www.naramed-u.ac.jp/~psy/