• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Study of central cholinergic activity, olfactory function, and duration of untreated psychosis in patients with schizophrenia

Research Project

Project/Area Number 23791350
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionWakayama Medical University

Principal Investigator

SHOYAMA Masaru  和歌山県立医科大学, 医学部, 博士研究員 (70364081)

Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords統合失調症 / SAI / アセチルコリン / 嗅覚障害 / 嗅覚 / 精神病未治療期間 / 経頭蓋磁気刺激
Outline of Final Research Achievements

We investigated central cholinergic activity and olfactory function in patients diagnosed with schizophrenia. For this study, we developed a novel device to easily measure short-latency afferent inhibition (SAI) as a putative marker of central cholinergic activity and found reduced SAI levels in schizophrenia patients. We also noted impaired odor identification performance in schizophrenia patients using a smell identification test card (Open Essence). Based on our results, we speculate that the central cholinergic circuit and neural substrates of odor identification are impaired by schizophrenia. Unfortunately we were not able to gather adequate data regarding the duration of untreated psychosis in these patients and additional studies are needed in order to clarify their relationship.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (19 results)

All 2015 2014 2013 2012 2011

All Journal Article (12 results) (of which Peer Reviewed: 9 results) Presentation (6 results) Book (1 results)

  • [Journal Article] Evaluation of regional cerebral blood flow in patient with atypical senile dementia with asymmetrical calcification2015

    • Author(s)
      Masaru Shoyama, Satoshi Ukai, Kazuhiro Shinosaki
    • Journal Title

      Psychogeriatrics

      Volume: 3 Issue: 4 Pages: 272-276

    • DOI

      10.1111/psyg.12110

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 緊張病性昏迷に対してolanzapine速効型筋注製剤が有効であった1例2014

    • Author(s)
      正山勝
    • Journal Title

      精神医学

      Volume: 56巻 Pages: 511-513

    • NAID

      40020093914

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 漢方臨床レポート 軽症抑うつ状態への抑肝散加陳皮半夏の使用経験(解説)2014

    • Author(s)
      正山 勝
    • Journal Title

      Phil漢方

      Volume: 10 Pages: 18-20

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Short Latency Afferent Inhibition In Schizophrenia Patients2013

    • Author(s)
      Masaru Shoyama, Shun Takahashi, Tadahiro Hashimoto, Tomikimi Tsuji, Satoshi Ukai, Kazuhiro Shinosaki
    • Journal Title

      ASEAN Journal of Psychiatry

      Volume: 14 Pages: 126-133

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Short latency afferent inhibition(SAI)の簡易測定装置の検討2013

    • Author(s)
      正山 勝, 辻 富基美, 鵜飼 聡, 篠崎和弘
    • Journal Title

      臨床神経生理学

      Volume: 41巻 Pages: 444-444

    • Related Report
      2013 Research-status Report
  • [Journal Article] 高用量のaripiprazole、quetiapineが有効であった遅発性パラフレニーの1例2013

    • Author(s)
      正山 勝
    • Journal Title

      臨床精神薬理

      Volume: 16巻 Pages: 1517-1520

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 漢方による向精神薬の多剤併用の防止2013

    • Author(s)
      正山 勝
    • Journal Title

      日本精神科病院協会雑誌

      Volume: 32 Pages: 52-56

    • Related Report
      2013 Research-status Report
  • [Journal Article] 体動制限下での皮膚そう痒症に抑肝散が有効であった1例2013

    • Author(s)
      正山 勝
    • Journal Title

      漢方と診療

      Volume: 4巻 Pages: 37-37

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 酸棗仁湯で便秘が改善した1例2013

    • Author(s)
      正山 勝
    • Journal Title

      漢方と診療

      Volume: 4巻 Pages: 121-123

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mirtazapine投与後に悪夢が生じた1例.2012

    • Author(s)
      正山勝、辻富基美、鵜飼聡、篠崎和弘
    • Journal Title

      精神科治療学

      Volume: 27 Pages: 401-405

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mirtazapine投与後に悪夢が生じた1例2012

    • Author(s)
      正山 勝,辻 富基美,鵜飼 聡,篠崎和弘
    • Journal Title

      精神科治療学

      Volume: 27 Pages: 401-405

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Brain activity during the Clock-Drawing Test: multichannel near-infrared spectroscopy study.2011

    • Author(s)
      Shoyama M, Nishioka T, Okumura M, Kose A, Tsuji T, Ukai S, Shinosaki K.
    • Journal Title

      Applied Neuropsychology

      Volume: 18 Issue: 4 Pages: 243-51

    • DOI

      10.1080/09084282.2011.595450

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 統合失調症患者でのカード型嗅覚同定検査法(Open essense)の検討2015

    • Author(s)
      正山 勝, 篠崎 和弘
    • Organizer
      第111回日本精神神経学会学術総会
    • Place of Presentation
      大阪市
    • Year and Date
      2015-06-04 – 2015-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 頭部外傷性精神病性障害の認知機能の不均衡2015

    • Author(s)
      正山 勝, 篠崎 和弘
    • Organizer
      第116回近畿精神神経学会
    • Place of Presentation
      高槻市
    • Year and Date
      2015-02-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Short latency afferent inhibition(SAI)の簡易測定装置の検討2013

    • Author(s)
      正山 勝, 辻 富基美, 鵜飼 聡, 篠崎和弘
    • Organizer
      第43回日本臨床神経生理学会学術大会
    • Place of Presentation
      高知市
    • Related Report
      2013 Research-status Report
  • [Presentation] 統合失調症認知機能簡易評価尺度(BACS)による近赤外線分光法の検討2012

    • Author(s)
      正山勝
    • Organizer
      第14回和歌山ファンクショナルニューロイメージングカンファレンス
    • Place of Presentation
      和歌山市
    • Related Report
      2012 Research-status Report
  • [Presentation] エキス製剤の投与後に砂状の便を認めた神経性食思不振症、クローン病の一例.2012

    • Author(s)
      正山勝
    • Organizer
      第63回日本東洋医学会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] 桂枝茯苓丸と向精神薬の相互作用が疑われた一例.2012

    • Author(s)
      正山勝
    • Organizer
      平成24年度日本東洋医学会関西支部例会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Book] 臨床各科で遭遇する幻覚妄想 耳鼻咽喉科領域:脳とこころのプライマリケア第6巻 幻覚と妄想2011

    • Author(s)
      正山 勝、篠崎和弘
    • Publisher
      シナジー
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi