Study on mood disorder pathogenesis using a novel animal model of bipolar disorders expressing protein of human herpesvirus.
| Project/Area Number |
23791355
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 双極性障害 / 気分障害 / ヒトヘルペスウイルス6 / SITH-1 / 動物モデル / 炎症性サイトカイン / BDNF / うつ病 / HHV-6 / ヒトヘルペスウイルス６ |
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| Research Abstract |
Small protein encoded by the Intermediate stage Transcript of Human herpesvirus (HHV-)6 (SITH) -1, a latent transcript of HHV-6, causes depressive-like behavior by being expressed in mouse astrocytes. Inflammatory cytokine mRNA levels did not change in the brains of mice. On the other hand, inflammatory cytokine mRNA blood levels and depressive symptom severity were correlated with mood disorders in human patients. Gene expression in peripheral blood and the central nervous system (CNS) do not necessarily coincide. Systemic inflammation affects the CNS and induction of SITH-1 may cause depressive symptoms.
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Report
(4 results)
Research Products
(15 results)
