| Project/Area Number |
23791356
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 非定型精神病 / 臨床診断基準 / GWAS / 全ゲノム関連解析 / 統合失調症 / 双極性障害 / 内因性精神病 / 多型 / 遺伝子 / 分子遺伝学 / 遺伝子解析 / 病因探索 |
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| Research Abstract |
The most significant SNPs were detected around the CHN2/CPVL genes (rs245914, p=1.6×10-7), COL21A1 gene (rs12196860, p=2.45×10-7), and PYGL/TRIM9 genes (rs1959536, p=7.73×10-7), although none of the single-nucleotide polymorphisms exhibited genome-wide significance (p=5×10-8). One of the highest peaks was detected on the major histocompatibility complex region, where large SZ GWASs have previouslydisclosed an association. The gene-based analysis suggested significant enrichment between SZ and atypical psychosis (p=0.01), but not BD. CONCLUSIONS: This study provides clues about the types of patient whose diagnosis lies between SZ and BD. Studies with larger samples are required to determine the causal variant.
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