| Project/Area Number |
23791363
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MAEKAWA Motoko 独立行政法人理化学研究所, 分子精神科学研究チーム, 研究員 (50435731)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 母乳 / 統合失調症 / C57BL/6 マウス / C3H/He マウス / PPI / 脂肪酸 / ビタミン / アミノ酸 / C57BL/6Nマウス / C3H/HeNマウス / 母子間伝達物質 / FABP7 / B6マウス / C3マウス / 栄養 / 環境要因 |
|---|
| Research Abstract |
Schizophrenia is a debilitating mental disorder that afflicts about 1% of the population worldwide. Despite intensive and multifaceted research, its exact etiology remains largely elusive. The neurodevelopmental hypothesis of schizophrenia suggests that subtle disturbances occurred in early brain development increases the risk of later schizophrenia development. Accordingly, various prenatal and perinatal risk factors have been linked to schizophrenia, including exposures related to infection, malnutrition and obstetric complications. Currently, we have revisited the importance of relevant epidemiological data: “Dutch Hunger Winter in 1944 to 1945” and “A massive 1959-1961 famine in China”. These epidemiological data show that when pregnant mothers experienced malnutrition or famine, the risk of schizophrenia in their children increased by about two fold. Therefore, we addressed the potential nutritional factors of mental disorders including schizophrenia by using mice.
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