| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
We focused on schizophrenia with enhanced carbonyl stress. In this study, we identified genetic variants in AGER which is important gene regulating carbonyl stress. Subjects carrying minor allele in identified variants showed significant decreased esRAGE levels leading to impairment of reducing carbonyl stress. As for clinical investigation, we found that clinical features of schizophrenia with the stress were similar to those of treatment-resistant schizophrenia by Kane et al. We have done the clinical trial for patients with enhanced carbonyl stress by adding high dose vitamin B6.
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