| Project/Area Number |
23791371
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
FUJII Takashi 独立行政法人国立精神・神経医療研究センター, 神経研究所 疾病研究第三部, 科研費研究員 (10450610)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 神経科学 / 脳神経疾患 / ストレス応答生理 / ABCトランスポーター / 認知機能解析 / 遺伝子解析 / 大うつ病性障害 / 統合失調症 |
|---|
| Research Abstract |
In this study, we focused on ABC transporter family, which might be involved in the pathogenesis of schizophrenia and major depressive disorder (MDD). First, we reported a significant association between the rs2230808 (R1587K) of ABCA1 and schizophrenia in men. In the study of ABCB1 encoding the P-glycoprotein gene, we selected the five functional polymorphisms (A-41G [rs2188524], T-129C [rs3213619], C1236T [rs1128503], G2677A/T [rs2032582], and C3435T [rs1045642]). We found that the minor T3435 allele of rs1045642 was significantly increased in MDD patients than in the controls and homozygotes for the T3435 allele was significantly more common in patients than in the controls. These results suggest that the T3435 allele or carrying two copies of this allele confers susceptibility to MDD in the Japanese population.
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