| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
In this study, I revealed the molecular mechanism of intermittent hypoxia-induced rasioresistance in tumor cells as follows;
The preconditioning of tumor cells with intermittent hypoxia increased the radioresistance compared to normoxia and persistent hypoxia.
The treatment of intermittent hypoxia induced the production of reactive oxygen species and the over-expression of the hypoxia inducible factor-1α, suggesting the involvement of cellular redox status and hypoxia-response signal pathway in the biological effect of intermittent hypoxia.
The treatment of intermittent hypoxia decreased the fraction of the relative radiosensitive early S phase and increased that of the radioresistant G2 phase.
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