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Development of noninvasive imaging biomarker for early diagnosis and prediction of outcome of intractable diseases of the central nervous system

Research Project

Project/Area Number 23791380
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionHokkaido University

Principal Investigator

THA KHIN KHIN  北海道大学, 医学(系)研究科(研究院), 特任講師 (20451445)

Research Collaborator TERAE Satoshi  北海道大学, 大学院医学研究科, 客員教授 (40240634)
YABE Ichiro  北海道大学, 大学院医学研究科, 准教授 (60372273)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords拡散テンソル / 神経難病 / 頚髄 / 脳 / MRI
Research Abstract

This study evaluated if the major diffusion tensor imaging (DTI) metrics of the brain and the spinal cord can become the quantitative metrics for noninvasive evaluation of intractable diseases of the central nervous system.
Significant alterations in the major DTI metrics were observed in sporadic amyotrophic lateral sclerosis, multiple sclerosis, and neuromyelitis optica spectrum disorders, despite no abnormality on the routine MRI sequences. The abnormalities detected on DTI are thought to reflect axonal loss and/ or demyelination. In sporadic amyotrophic lateral sclerosis, the DTI abnormalities correlated strongly with the scores which determine disease severity or progression. In conclusion, DTI is considered a sensitive technique to detect the microstructural abnormalities of the brain and the spinal cord in the intractable diseases of the central nervous system; and can be used to noninvasively quantify the severity or progression of these diseases.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (21 results)

All 2014 2013 2012 Other

All Journal Article (2 results) Presentation (18 results) (of which Invited: 1 results) Remarks (1 results)

  • [Journal Article] Laterality of the corticospinal tract and the influence of handedness : the findings of a DTI study2013

    • Author(s)
      Tha KK, Terae S, Hamaguchi H, Ishizaka K, Popy KA, Hirotani M, Sugimori H, Fujima N, Yoshida A, Minowa K, Suzuki Y, Shirato H.
    • Journal Title

      日本磁気共鳴医学会雑誌

      Volume: 33 (1)(現在2件投稿中) Pages: 33-34

    • NAID

      10031163469

    • Related Report
      2013 Final Research Report
  • [Journal Article] Laterality of the corticospinal tract and the influence of handedness: the findings of a DTI study.2013

    • Author(s)
      Tha KK, Terae S, Hamaguchi H, Ishizaka K, Popy KA, Hirotani M, Sugimori H, Fujima N, Yoshida A, Minowa K, Suzuki Y, Shirato H.
    • Journal Title

      日本磁気共鳴医学会雑誌

      Volume: 33 (1) Pages: 33-34

    • NAID

      10031163469

    • Related Report
      2013 Annual Research Report
  • [Presentation] 小脳白質 : 解剖と疾患(仮)2014

    • Author(s)
      Tha KK
    • Organizer
      第7回Neuro-imaging Refresher Club
    • Place of Presentation
      東京
    • Year and Date
      2014-11-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Regional DTI metrics of the cervical spinal cord in sporadic amyotrophic lateral sclerosis2014

    • Author(s)
      Tha KK, Yabe I, Terae S, Hirotani M, Hamaguchi H, Suzuki Y, Okuaki T, Minowa K, Sasaki H, Shirato H.
    • Organizer
      第73回日本放射線学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] The effect of respiratory and cardiac gating on the major diffusion imaging metrics2014

    • Author(s)
      Hamaguchi H, Tha KK, Sugimori H, Nakanishi M, Nakagawa S, Fujiwara T, Yoshida H, Takamori S, Shirato H.
    • Organizer
      European Congress of Radiology
    • Place of Presentation
      Vienna、Austria
    • Related Report
      2013 Final Research Report
  • [Presentation] Regional DTI metrics of the cervical spinal cord in sporadic amyotrophic lateral sclerosis2014

    • Author(s)
      Tha KK, Yabe I, Terae S, Hirotani M, Hamaguchi H, Suzuki Y, Okuaki T, Minowa K, Sasaki H, Shirato H
    • Organizer
      第73回日本放射線学会
    • Place of Presentation
      Pacifico Yokohama(横浜)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The effect of respiratory and cardiac gating on the major diffusion imaging metrics2014

    • Author(s)
      Hamaguchi H, Tha KK, Sugimori H, Nakanishi M, Nakagawa S, Fujiwara T, Yoshida H, Takamori S, Shirato H
    • Organizer
      European Congress of Radiology
    • Place of Presentation
      Austria Center(Vienna, Austria)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 体内水分子の拡散を非侵襲的に観察するMRI撮像法 : 現状と将来展望2013

    • Author(s)
      Tha KK
    • Organizer
      第78回未来医療イノベーションセミナー
    • Place of Presentation
      札幌
    • Year and Date
      2013-04-10
    • Related Report
      2013 Final Research Report
  • [Presentation] The ascending sensory pathways may not be spared in amyotrophic lateral sclerosis2013

    • Author(s)
      Tha KK, Yabe I, Terae S , Hirotani M, Hamaguchi H, Ishizaka K, Suzuki Y, Okuaki T, Minowa K, Sasaki H, Shirato H.
    • Organizer
      The 11^<th> International Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] Laterality of the corticospinal tract and variation with handedness : a diffusion tensor imaging observation2013

    • Author(s)
      Tha KK, Terae S, Hamaguchi H, Ishizaka K, Hirotani M, Minowa K, Suzuki Y, Shirato H.
    • Organizer
      ISMRM 21^<st> Annual Meeting & Exhibition
    • Place of Presentation
      Salt Lake City、USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Diffusion tensor imaging characteristics of the normal human corticospinal tract2013

    • Author(s)
      Tha KK, Terae S, Hamaguchi H, Ishizaka K, Hirotani M, Okuakai T, Suzuki Y, Minowa K, Shirato H.
    • Organizer
      第42回日本神経放射線学会
    • Place of Presentation
      北九州
    • Related Report
      2013 Final Research Report
  • [Presentation] The ascending sensory pathways may not be spared in amyotrophic lateral sclerosis2013

    • Author(s)
      Tha KK, Yabe I, Terae S, Hirotani M, Hamaguchi H, Ishizaka K, Suzuki Y, Okuaki T, Minowa K, Sasaki H, Shirato H
    • Organizer
      The 11th International Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      Science Bldg. No. 5, 2nd Floor, Graduate School of Science, Hokkaido University (札幌)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Diffusion tensor imaging characteristics of the normal human corticospinal tract2013

    • Author(s)
      Tha KK, Terae S, Hamaguchi H, Ishizaka K, Hirotani M, Okuakai T, Suzuki Y, Minowa K, Shirato H
    • Organizer
      第42回日本神経放射線学会
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Related Report
      2012 Research-status Report
  • [Presentation] Laterality of the corticospinal tract and variation with handedness: a diffusion tensor imaging observation2013

    • Author(s)
      Tha KK, Terae S, Hamaguchi H, Ishizaka K, Hirotani M, Minowa K, Suzuki Y, Shirato H
    • Organizer
      ISMRM 21st Annual Meeting & Exhibition
    • Place of Presentation
      Salt Palace Convention Center(USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] Laterality of the corticospinal tract and influence of handedness : a diffusion tensor imaging observation2012

    • Author(s)
      Tha KK, Terae S, Hamguchi H, Ishizaka K, Popy KA, Hirotani M, Minowa K, Suzuki Y, Shirato H.
    • Organizer
      The 10^<th> International Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] Laterality of the corticospinal tract and influence of handedness : a diffusion tensor imaging observation2012

    • Author(s)
      Tha KK, Terae S, Hamaguchi H, Ishizaka K, Popy KA, Hirotani M, Sugimori H, Fujima N, Yoshida A, Minowa K, Suzuki Y, Shirato H.
    • Organizer
      第40回日本磁気共鳴医学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] Laterality of the corticospinal tract and influence of handedness: a diffusion tensor imaging observation2012

    • Author(s)
      Tha KK, Terae S, Hamaguchi H, Ishizaka K, Popy KA, Hirotani M, Sugimori H, Fujima N, Yoshida A, Minowa K, Suzuki Y, Shirato H
    • Organizer
      第40回日本磁気共鳴医学会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2012 Research-status Report
  • [Presentation] Laterality of the corticospinal tract and influence of handedness: a diffusion tensor imaging observation2012

    • Author(s)
      Tha KK, Terae S, Hamaguchi H, Ishizaka K, Popy KA, Hirotani M, Minowa K, Suzuki Y, Shirato H
    • Organizer
      The 10th International Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      北海道大学フラテ会館(札幌市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 体内水分子の拡散を非侵襲的に観察するMRI撮像法:現状と将来展望

    • Author(s)
      タキンキン
    • Organizer
      第78回 未来医療イノベーションセミナー
    • Place of Presentation
      北海道大学大学院医学研究科医学部学友会館「フラテ」1階 大研修室〔札幌)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 小脳白質ー解剖と疾患(仮)

    • Author(s)
      タキンキン
    • Organizer
      第7回 Neuro- Imaging Refresher Club
    • Place of Presentation
      東京コンファレンスセンター品川〔東京)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Remarks] FA database

    • URL

      http://rad.med.hokudai.ac.jp/research2/fa/

    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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