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Establishment of coil-assisted NBCA embolization technique-Toward the standardization of vascular embolization

Research Project

Project/Area Number 23791381
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionHokkaido University

Principal Investigator

ABO Daisuke  北海道大学, 北海道大学病院, 助教 (30399844)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords血管塞栓術 / コイル / N-Butylcyanoacrylate / 標準化
Research Abstract

To establish the methodology and assess feasibility of coil-assisted N-butyl-2-cyanoacrylate (NBCA) embolization technique, thirty-eight arteries of three swine were embolized as target arteries.
In half of the target arteries, a single anchoring coil was placed (Group A; n=19). In the remaining, a coil mixture made by coil-in-coil technique was used(Group B; n=19). In both groups, 50% NBCA-lipiodol mixture (50%NBCA) was injected via microcatheter Flow delay after coil placement, the length of cast formation over the coil mass(>1cm) and cast fragmentation were evaluated.
As a result, all arteries occluded just after embolization. Flow delay after coil placement occurred more frequently in Group B (11/19) than in Group A (4/19) (p=0.0448). Cast formation over the coil mass and cast fragmentation were observed less frequently in Group B (3/19 and 4/19, respectively) than in Group A (9/19 and 7/19, respectively) (p=0.0463 and 0.0489). Cast formation over the coil mass occurred less frequently in the arteries with flow delay (1/15), compared to their counterparts (13/23) (p=0.0021).Cast fragmentation did not occur in any artery with flow delay (p<0.001).
From these results, we concluded that coil-assisted NBCA embolization technique is feasible for embolization in short segment of target vessels, if the coil induces a sufficient flow delay. Coil-in-coil technique is recommended to enhance flow delay.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2013 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (7 results)

  • [Journal Article] Feasibility of a dual microcatheter-dual interlocking detachable coil technique in preoperative embolization in preparation for distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic body cancer2012

    • Author(s)
      Abo D, Hasegawa Y, Sakuhara Y, Terae S, Shimizu T, Tha KK, Tanaka E, Hirano S, Kondo S, Shirato H
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 19(4) Issue: 4 Pages: 431-437

    • DOI

      10.1007/s00534-011-0455-9

    • NAID

      10030951022

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 豚動脈を用いたコイル併用 n-butyl-2-cianoacrylate (NBCA) 塞栓術の実現性の検討2013

    • Author(s)
      阿保大介
    • Organizer
      第42回日本IVR学会総会
    • Place of Presentation
      軽井沢市軽井沢プリンスホテル
    • Year and Date
      2013-05-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 豚動脈を用いたコイル併用 n-butyl-2-cianoacrylate (NBCA) 塞栓術の実現性の検討2013

    • Author(s)
      阿保大介
    • Organizer
      第72回日本医学放射線学会総会
    • Place of Presentation
      横浜市パ シフィコ横浜
    • Year and Date
      2013-04-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 豚動脈を用いたコイル併用 n-butyl-2-cianoacrylate (NBCA) 塞栓術の実現性の検討2013

    • Author(s)
      阿保大介
    • Organizer
      第59回北海道IVR研究会
    • Place of Presentation
      札幌市北海道大学
    • Year and Date
      2013-02-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Feasibility of a dual microcatheter-dual interlocking detachable coil technique in preoperative embolization in preparation for distal pancreatectomy with en bloc celiac axis resection for locally advanced pancreatic body cancer2011

    • Author(s)
      Abo D, Hasegawa Y, Sakuhara Y, Terae S, Shimizu T, Tanaka E, Hirano S, Shirato H
    • Organizer
      CIRSE2011
    • Place of Presentation
      The Internationales Congress Center・ドイツ・ミュンヘン
    • Related Report
      2011 Research-status Report
  • [Presentation] 腹腔動脈幹合併切除兼尾側膵切除(DP-CAR)術前総肝動脈塞栓術の検討~dual microcatheter法とconventional法との比較~2011

    • Author(s)
      阿保大介,作原祐介,長谷川悠,曽山武士,森田亮,坂本圭太,白土博樹,寺江聡,清水匡,田中栄一,平野聡
    • Organizer
      第40回日本IVR学会総会
    • Place of Presentation
      青森(青森文化会館/ホテル青森)
    • Related Report
      2011 Research-status Report
  • [Presentation] 膵頭十二指腸切除術後膵液瘻に対する非観血的内瘻化2011

    • Author(s)
      阿保大介,長谷川悠,作原祐介,森田亮,曽山武士,白土博樹,寺江聡,清水匡,田中栄一,平野聡51.阿保大介,長谷川悠,作原祐介,森田亮,曽山武士,白土博樹,寺江聡,清水匡,田中栄一,平野聡
    • Organizer
      第40回日本IVR学会総会
    • Place of Presentation
      青森(青森文化会館/ホテル青森)
    • Related Report
      2011 Research-status Report
  • [Presentation] 豚動脈を用いたコイル併用N-butyl-2-cyanoacrylate (NBCA)塞栓術の実現性の検討

    • Author(s)
      阿保大介
    • Organizer
      第59回北海道血管造影IVR研究会
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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