Carotid plaque characteristics in Japanese population using 3-Tesla MRI

• Project/Area Number: 23791385
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: OTA Hideki 東北大学, 大学病院, 助教 (40586905)
• Research Collaborator: DEMARCO J. Kevin ; TAMURA Hajime ; ITABASHI Ryo
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 動脈硬化 / MRI / 頸動脈 / 国際情報交換 / plaque imaging / 脳卒中 / 放射線診断 / Plaque Imaging / 磁気共鳴画像 / 国際情報交流 / Plaque imaging / 核磁気共鳴画像

Outline of Final Research Achievements

The purpose of this prospective study was to explore carotid plaque characteristics of Japanese population using 3-Tesla MRI.
Carotid plaque characteristics in a specific atherosclerotic population appeared different between Japanese (Asian) and Caucasian Americans. In Japanese population, symptomatic carotids had high-risk plaque features more frequently than asymptomatic carotids.
This study indicated that evaluation of Japanese carotid plaque characteristics using 3-Tesla MRI is feasible; it also demonstrated association of high-risk plaque characteristics with cerebrovascular ischemic events.

Research Products

• [Presentation] ハイリスク頸動脈プラークをMRIで評価する (2015)
  • Author(s): 大田英揮
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪（大阪国際会議場）
  • Year and Date: 2015-04-24 – 2015-04-26
  • Invited
• [Presentation] 症例から学ぶ体幹部・末梢動脈のMRA撮像法と画像診断 (2014)
  • Author(s): 大田英揮
  • Organizer: 第34回 群馬MRI研究会
  • Place of Presentation: 前橋（群馬大学医学部附属病院）
  • Year and Date: 2014-10-03
  • Invited
• [Presentation] Longitudinal relaxation time and apparent diffusion coefficient for human carotid plaque segmentation at 3T with histological comparison. (2014)
  • Author(s): Hideki Ota, Mika Watanabe, Tatsuo Nagasaka, Makoto Obara, Hajime Tamura.
  • Organizer: 26th Annual Meeting of the International Magnetic Resonance Angiography Conference.
  • Place of Presentation: Rome, Italy
  • Year and Date: 2014-09-16 – 2014-09-19
• [Presentation] MRIを用いた頸動脈プラークイメージング (2014)
  • Author(s): 大田英揮
  • Organizer: 第4回Advanced CT/MRI 研究会
  • Place of Presentation: 軽井沢（軽井沢プリンスホテルウェスト）
  • Year and Date: 2014-06-14 – 2014-06-15
  • Invited
• [Presentation] Longitudinal Relaxation Time and Apparent Diffusion Coefficient in Human Carotid Plaque at 3T: Phantom Validation and Histological Comparison. (2014)
  • Author(s): Hideki Ota, Mika Watanabe, Tatsuo Nagasaka, Makoto Obara, Hajime Tamura
  • Organizer: 22nd International Society of Magnetic Resonance in Medicine. Milan, Italy. 10-16 May, 2014
  • Place of Presentation: Milan, Italy
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] 頸動脈プラークMRIの臨床応用 (2014)
  • Author(s): 大田英揮
  • Organizer: 第35回 松山脳神経外科会 特別講演会
  • Place of Presentation: 松山（大和屋本店）
  • Year and Date: 2014-04-25
  • Invited
• [Presentation] Comparison of Carotid Plaque Characteristics Between Japanese and Midwest American Caucasian Patients with Coronary Artery Disease: A 3.0T MRI Study. (2013)
  • Author(s): Hideki Ota, J Kevin DeMarco, Minako Wakayama, David C Zhu, Kei Takase, Shoki Takahashi.
  • Organizer: 21st International Society of Magnetic Resonance in Medicine.
  • Place of Presentation: Salt Lake City, USA
• [Presentation] Vessel wall imaging の臨床応用 (2013)
  • Author(s): 大田 英揮
  • Organizer: 日本磁気共鳴医学会
  • Place of Presentation: 徳島
• [Presentation] Comparison of Carotid Plaque Characteristics Between Japanese and Midwest American Caucasian Patients with Coronary Artery Disease: A 3.0T MRI Study. (2013)
  • Author(s): Hideki Ota, J Kevin DeMarco, Minako Oikawa, Zhu C David, Kei Takase, Shoki Takahashi
  • Organizer: 21st Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Salt Lake City, USA