Amyloid PET imaging in idiopathic normal-pressure hydrocephalus

• Project/Area Number: 23791388
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Tohoku University
• Principal Investigator: HIRAOKA Kotaro 東北大学, ラジオアイソトープセンター・サイクロトロン, 助教 (70586049)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 特発性正常圧水頭症 / アミロイドβ蛋白 / PET(陽電子放射断層撮影 ) / PET (陽電子放射断層撮影 ） / アミロイド蛋白 / PET / 脳脊髄液シャント術

Research Abstract

Amyloid PET imaging was performed in 5 iNPH (idiopathic normal-pressure hydrocephalus) patients before shunt surgery. The results suggested that there were not so much neocortical amyloid deposits in these cases. We are planning to perform amyloid imaging on more iNPH patients, and verify the usefulness of amyloidimaging in predicting treatment effects of shunt surgery.

Research Products

• [Journal Article] Cholinergic Deficit and Response to Donepezil Therapy in Parkins on's Disease with Dementia (2012)
  • Author(s): Hiraoka K, Okamura N, Funaki Y, Hay ashi A, Tashiro M, Hisanaga K, Fuji i T, Takeda A, Yanai K, Iwata R, Mo ri E.
  • Journal Title: Eur Neu rol Volume: 68 Pages: 137-143
  • URL: http://www.karger.com/Article/FullText/338774
  • Peer Reviewed
• [Journal Article] [ (11)C] Doxepin binding to histamine H1 receptors in living human brain: reproducibility during attentive waking and circadian rhythm (2012)
  • Author(s): KatsuhikoShibuya
  • Journal Title: FrontiersinSystemsNeuroscience Volume: 6 Pages: 1-7
  • DOI: 10.3389/fnsys.2012.00045
  • Peer Reviewed
• [Journal Article] Total aortic arch replacement using hypothermic circulatory arrest with antegrade selective cerebral perfusion: are there cerebral deficits other than frank stroke? (2012)
  • Author(s): Kotaro Hiraoka
  • Journal Title: General thoracic and cardiovascular surgery Volume: 60 Issue: 6 Pages: 345-349
  • DOI: 10.1007/s11748-012-0057-8
  • NAID: 10031121113
  • Peer Reviewed
• [Journal Article] A Validation Study of the Japanese Version of the Addenbrooke’s Cognitive Examination-Revised (2012)
  • Author(s): Dos Santos Kawata KH
  • Journal Title: Dementia and geriatric cognitive disorders extra Volume: 2 Issue: 1 Pages: 29-37
  • DOI: 10.1159/000336909
  • Peer Reviewed
• [Journal Article] Counting-backward test for executive function in idiopathic normal pressure hydrocephalus (2012)
  • Author(s): Kanno S, Saito M, Hayashi A, Uchiyama M, Hiraoka K, Nishio Y, Hisanaga K, Mori E
  • Journal Title: Acta Neurol Scand Volume: (印刷中) Issue: 4 Pages: 279-286
  • DOI: 10.1111/j.1600-0404.2012.01644.x
  • Peer Reviewed
• [Journal Article] カイロプラクティック施術の神経生理学的影響に関する検討 (2012)
  • Author(s): 小倉毅、田代学、四月朔日聖一、マスッド・メヘディ、渋谷勝彦、稲見暁恵、三宅正泰、平岡宏太良、山口慶一郎、谷内一彦
  • Journal Title: 日本統合医療学会誌 Volume: 5(2) Pages: 1-6
  • URL: http://colors-cp.com/genkou.pdf
  • Peer Reviewed
• [Journal Article] カイロプラクティック施術の神経生理学的影響に関する検討 (2012)
  • Author(s): 小倉 毅
  • Journal Title: 日本統合医療学会誌 Volume: 5 Pages: 1-6
  • Peer Reviewed
• [Journal Article] Cholinergic deficit and response to donepezil therapy in Parkinson's disease with dementia (2012)
  • Author(s): Hiraoka K, Okamura N, Funaki Y, Hayashi A, Tashiro M, Hisanaga K, Fujii T, Takeda A, Y anai K, Iwata R, Mori E
  • Journal Title: Eur Neurol Volume: 68 Issue: 3 Pages: 137-143
  • DOI: 10.1159/000338774
  • Peer Reviewed
• [Journal Article] 微量放射性薬剤を用いたナノバイオイメージング研究と健康科学への応用 (2012)
  • Author(s): 田代学、平岡宏太良、四月朔日聖一、三宅正泰、マスッド・メヘディ、熊谷和明、小倉毅、谷内一彦、石井慶造
  • Journal Title: 東北大学グローバルCOEプログラム 新世紀世界の成長焦点に築くナノ医工学拠点 ナノ医工学年報2011 Volume: 5 Pages: 79-90
  • NAID: 40019249953
• [Journal Article] The effects of aging and Alzheimer's disease on associative recognition memory (2011)
  • Author(s): Hanaki R, Abe N, Fujii T, Ueno A, Nishio Y, Hiraoka K, Shimomura T, Iizuka O, Shinohara M, Hirayama K, Mori E
  • Journal Title: Neurological Science Volume: 32(6) Issue: 6 Pages: 1115-1122
  • DOI: 10.1007/s10072-011-0748-4
  • Peer Reviewed
• [Journal Article] White matte r involvement in idiopathic normal pressure hydrocephalus: a voxel-bas ed diffusion tensor imaging study (2011)
  • Author(s): Kanno S, Abe N, Saito M, Takagi M, Nishio Y, Hayashi A, Uchiyama M, Hanaki R, Kikuchi H, Hiraoka K, Yamas aki H, Iizuka O, Takeda A, Itoyama Y, Takahashi S, Mori E.
  • Journal Title: J Neurol Volume: 258(11) Issue: 11 Pages: 1949-57
  • DOI: 10.1007/s00415-011-6038-5
  • Peer Reviewed
• [Journal Article] False item recognition in patients with Alzheimer's disease (2011)
  • Author(s): Nobuhito Abe
  • Journal Title: Neuropsychologia Volume: 49(7) Issue: 7 Pages: 1897-1902
  • DOI: 10.1016/j.neuropsychologia.2011.03.015
  • Peer Reviewed
• [Journal Article] Is the midb rain involved in the manifestation of gait disturbance in idiopathic n ormal-pressure hydrocephalus? (2011)
  • Author(s): Hiraoka K, Yamasaki H, Takagi M, Sa ito M, Nishio Y, Iizuka O, Kanno S, Kikuchi H, and Mori E
  • Journal Title: Journal of Neurology Volume: 258(5) Issue: 5 Pages: 820-5
  • DOI: 10.1007/s00415-010-5847-2
  • Peer Reviewed
• [Journal Article] Is the midbrain involved in the manifestation of gait disturbance in idiopathic normal-pressure hydrocephalus? (2011)
  • Author(s): Hiraoka K, Yamasaki H, Takagi M, Saito M, Nishio Y, Iizuka O, Kanno S, Kikuchi H, and Mori E
  • Journal Title: Journal of Neurology Volume: 258 Pages: 820-825
  • Peer Reviewed
• [Journal Article] False item recognition in patients with Alzheimer's disease (2011)
  • Author(s): Abe N, Fujii T, Nishio Y, Iizuka O, Kanno S, Kikuchi H, Takagi M, Hiraoka K, Yamasaki H, Choi H, Hirayama K, Shinohara M, Mori E
  • Journal Title: Neuropsychologia Volume: 49 Pages: 1897-1902
  • Peer Reviewed
• [Journal Article] White matter involvement in idiopathic normal pressure hydrocephalus: a voxel-based diffusion tensor imaging study (2011)
  • Author(s): Kanno S, Abe N, Saito M, Takagi M, Nishio Y, Hayashi A, Uchiyama M, Hanaki R, Kikuchi H, Hiraoka K, Yamasaki H, Iizuka O, Takeda A, Itoyama Y, Takahashi S, Mori E
  • Journal Title: Journal of Neurology Volume: 258 Pages: 1949-1957
  • Peer Reviewed
• [Journal Article] The effects of aging and Alzheimer's disease on associative recognition memory (2011)
  • Author(s): Hanaki R, Abe N, Fujii T, Ueno A, Nishio Y, Hiraoka K, Shimomura T, Iizuka O, Shinohara M, Hirayama K, Mori E
  • Journal Title: Neurological Sciences Volume: 32 Pages: 1115-1122
  • Peer Reviewed
• [Presentation] 11C-doxepinを用いたPETによる抗ヒスタミン薬levocetirizineの脳内ヒスタミンH1受容体占拠率の測定 (2012)
  • Author(s): 平岡宏太良、田代学、石渡喜一、石井賢二、谷内一彦
  • Organizer: 第33回日本臨床薬理学会学術総会
  • Place of Presentation: 沖縄
  • Year and Date: 2012-11-29
• [Presentation] Amyloid imaging in iNPH (2012)
  • Author(s): Kotaro Hiraoka, Shigenori Kanno,Hirokazu Kikuchi, Manabu Tashiro, Nobuyuki Okamura, Katsutoshi Furukawa, Hiroyuki Arai, Ren Iwata, Etsuro Mori, Kazuhiko Yanai
  • Organizer: Hydrocephalus 2012
  • Place of Presentation: Kyoto
  • Year and Date: 2012-10-22
• [Presentation] 特発性正常圧水頭症患者における脳内アミロイド沈着の検出 (2012)
  • Author(s): 平岡宏太良、菅野重範、菊池大一、田代学、岡村信行、古川勝敏、荒井啓行、岩田錬、森悦朗、谷内一彦
  • Organizer: 第52回日本核医学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-10-12
• [Presentation] 認知症を伴うパーキンソン病におけるコリン神経系の障害とドネペジルによる治療効果 (2012)
  • Author(s): 平岡宏太良、岡村信行、船木善仁、林亜希子、田代学、久永欣哉、藤井俊勝、武田篤、谷内一彦、岩田錬、森悦朗
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-20
• [Presentation] 特発性正常圧水頭症患者における脳内アミロイド沈着の検出 (2012)
  • Author(s): 平岡宏太良、菅野重範、菊池大一、田代学、岡村信行、古川勝敏、荒井啓行、岩田錬、森悦朗、谷内一彦
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2012-05-25
• [Presentation] Cholinergic deficit and response to donepezil therapy inParkinson's disease with dementia: [5-11C-methoxy]donepezil-PET study (2012)
  • Author(s): Kotaro Hiraoka
  • Organizer: 64th AAN Annual Meeting
  • Place of Presentation: New Oreleans, USA
  • Year and Date: 2012-04-25
• [Presentation] Nano-bio-imaging withRadioharmaceuticals and Application to Health Sciences (2012)
  • Author(s): K. Hiraoka
  • Organizer: 18th International Symposium of Tohoku University Global COE Programme Global Nano-Biomedical Engineering Education and Research Network Centre
  • Place of Presentation: Tohoku University
  • Year and Date: 2012-03-05
• [Presentation] iNPHにおける脳内アミロイド蓄積量の計測 (2012)
  • Author(s): 平岡宏太良
  • Organizer: 第13回日本正常圧水頭症学会
  • Place of Presentation: 大阪
  • Year and Date: 2012-02-11
• [Presentation] Cholinergic deficit and response to donepezil therapy in Parkinson's disease with dementia (2012)
  • Author(s): Kotaro Hiraoka, Nobuyuki Okamura,Yoshihito Funaki, Akiko Hayashi, Manabu Tashiro, Kinya Hisanaga, Toshikatsu Fujii, Atsushi Takeda, Kazuhiko Yanai, Ren Iwata, and Etsuro Mori
  • Organizer: The JSPS-NRF Asian Science Seminar2012
  • Place of Presentation: Seoul, South Korea
• [Presentation] 11C-doxepin を用いたPET による抗ヒスタミン薬levocetirizine の脳内ヒスタミンH1 受容体占拠率の測定 (2012)
  • Author(s): 平岡宏太良
  • Organizer: 第33 回日本臨床薬理学会学術総会
  • Place of Presentation: 沖縄
• [Presentation] 特発性正常圧水頭症患者における脳内アミロイド沈着の検出 (2012)
  • Author(s): 平岡宏太良
  • Organizer: 第52 回日本核医学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 認知症を伴うパーキンソン病におけるコリン神経系の障害 とドネペジルによる治療効果 (2012)
  • Author(s): 平岡宏太良
  • Organizer: 第35 回日本神経科学大会
  • Place of Presentation: 名古屋
• [Presentation] 特発性正常圧水頭症患者における脳内アミロイド沈着の検出 (2012)
  • Author(s): 平岡宏太良
  • Organizer: 第53 回日本神経学会学術大会
  • Place of Presentation: 東京
• [Presentation] Cholinergic deficit and response to donepezil therapy in Parkinson’s disease with dementia: [ 5-11C-methoxy] donepezil-PET study (2012)
  • Author(s): Kotaro Hiraoka
  • Organizer: 64th American Academy of Neurology Annual Meeting
  • Place of Presentation: New Orleans, USA
• [Presentation] Nano-bio-imaging with Radioharmaceuticals and Application to Health Sciences (2012)
  • Author(s): K. Hiraoka
  • Organizer: 18th International Symposium of Tohoku University Global COE Programme Global Nano-Biomedical Engineering Education and Research Network Centre
  • Place of Presentation: Sendai, Miyagi, Japan
• [Presentation] Cholinergic deficit and response to donepezil therapy in Parkinson’s disease with dementia (2012)
  • Author(s): Kotaro Hiraoka, Nobuyuki Okamura, Yoshihito Funaki, Akiko Hayashi, Manabu Tashiro, Kinya Hisanaga, Toshikatsu Fujii, Atsushi Takeda, Kazuhiko Yanai, Ren Iwata, and Etsuro Mori
  • Organizer: The JSPS-NRF Asian Science Seminar 2012
  • Place of Presentation: Seoul, South Korea
• [Presentation] iNPHにおける脳内アミロイド蓄積量の計測 (2012)
  • Author(s): 平岡宏太良
  • Organizer: 第13回日本正常圧水頭症学会
  • Place of Presentation: 大阪府大阪市
• [Presentation] 認知障害を伴うパーキンソン病におけるdonepezilのアセチルコリンエステラーゼに対する結合:[5-11C-methoxy]donepezilを用いたPET研究 (2011)
  • Author(s): 平岡宏太良
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-18
• [Presentation] Changes in the volumes of the brain and cerebrospinal fluid spaces aftershunt surgery in idiopathic normal-pressure hydrocephalus (2011)
  • Author(s): Hiraoka, K., Takagi, M., Saito, M., Nishio, Y., Iizuka, O., Kanno, S., Kikuchi, H., Kondo, T. and Mori, E.
  • Organizer: Hydrocephalus 2011
  • Place of Presentation: Rigshospitalet, Copenhagen, Denmark
• [Presentation] Changes in the volumes of the brain and cerebrospinal fluid spaces after shunt surgery in idiopathic normal-pressure hydrocephalus (2011)
  • Author(s): Hiraoka, K., Takagi, M., Saito, M., Nishio, Y., Iizuka, O., Kanno, S., Kikuchi, H., Kondo, T. and Mori, E
  • Organizer: Hydrocephalus 2011
  • Place of Presentation: Copenhagen, Denmark
• [Presentation] 認知障害を伴うパーキンソン病におけるdonepezilのアセチルコリンエステラーゼに対する結合：[5-11C-methoxy]donepezilを用いたPET研究 (2011)
  • Author(s): 平岡宏太良
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 愛知県名古屋市
• [Book] NANO-BIOMEDICAL ENGINEERING, 2012 Proceedings of the Tohoku University Global Centre of Excellence Programme, Global Nano-Biomedical Engineering Education and Research Network Centre (2012)
  • Author(s): Kotaro Hiraoka, Manabu Tashiro, Yoshihito Funaki, Nobuyuki Okamura, Toshikatsu Fujii, Atsushi Takeda, Kinya Hisanaga, Hiroshi Watabe, Ren Iwata, Etsuro Mori, And Kazuhiko Yanai
  • Publisher: [5-11c-methoxy]donepezil, a PET ligand for in-vivo visualization of donepezil binding to acetylcholinesterase and cholinergic imaging