Study on high-precision carbon-ion treatment for tumors with respiratory motion by 4-dimensional treatment planning

• Project/Area Number: 23791397
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Gunma University
• Principal Investigator: TASHIRO Mutsumi 群馬大学, 重粒子線医学推進機構, 助教 (60447274)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 放射線治療 / 粒子線治療 / 4D CT / 治療計画 / 呼吸性移動 / 線量分布 / 重粒子線治療 / 呼吸同期照射 / 4D-CT / 4次元治療計画

Research Abstract

The system environment has been created, which can deal with actual clinical CT data using a deformable fusion (registration) software for the respiratory motion evaluation with 4DCT images. A treatment-planning support tool has been also installed to be able to calculate dose distributions for a number of 3DCT images (4DCT image) at one time with an identical treatment plan condition. By use of these tools, accumulated dose distributions could be derived for CT images with different patient positions and/or with respiratory motion and deformation by considering such motion and deformation. Target dose coverage with motion and deformation could be evaluated.

Research Products

• [Journal Article] Technical approach to individualized respiratory-gated carbon-ion therapy for mobile organs (2013)
  • Author(s): M. Tashiro, T. Ishii, J. Koya, R. Okada, Y. Kurosawa, K. Arai, S. Abe, Y. Ohashi, H. Shimada, K. Yusa, T. Kanai, S. Yamada, H. Kawamura, T. Ebara, T. Ohno, T. Nakano
  • Journal Title: Radiological Physics and Technology Volume: (in press) Issue: 2 Pages: 356-366
  • DOI: 10.1007/s12194-013-0208-3
  • Peer Reviewed
• [Journal Article] Carbon Ion Radiotherapy at the Gunma University Heavy Ion Medical Center: New Facility Set-up (2011)
  • Author(s): T. Ohno, T. Kanai, S. Yamada, K. Yusa, M. Tashiro, H. Shimada, K. Torikai, Y. Yoshida, Y. Kitada, H. Kato, T. Ishii, T. Nakano
  • Journal Title: Cancers Volume: 3 Issue: 4 Pages: 4046-4060
  • DOI: 10.3390/cancers3044046
  • Peer Reviewed
• [Journal Article] 群馬大学重粒子線医学センターのご紹介 (2011)
  • Author(s): 田代睦
  • Journal Title: 放射線化学 Volume: 92 Pages: 33-37
  • URL: http://www.radiation-chemistry.org/kaishi/092pdf/92_33.pdf
  • Peer Reviewed
• [Presentation] 重粒子線治療における位置精度について～治療計画および位置決めの現状と展望～ (2012)
  • Author(s): 田代睦
  • Organizer: 第47回群馬放射線腫瘍研究会
  • Place of Presentation: 群馬大学医学部刀城会館(群馬県前橋市)
  • Year and Date: 2012-09-29
• [Presentation] INVESTIGATION OF RESPIRATORY-GATED CARBON TREATMENT USING MOTION-INCLUDED DOSE DISTRIBUTION (2012)
  • Author(s): M. Tashiro
  • Organizer: The 31st Sapporo International Cancer Symposium Advanced Radiation Therapy and Cancer Research
  • Place of Presentation: 北海道大学(札 幌市)
  • Year and Date: 2012-07-23
• [Presentation] Investigation of Respiratory-Gated Carbon Treatment Planning Using Motion-Included Dose Distribution (2012)
  • Author(s): M. Tashiro
  • Organizer: 51st Annual Meeting of Particle Therapy Co-Operative Group (PTCOG51)
  • Place of Presentation: Seoul(Korea)
  • Year and Date: 2012-05-14
• [Presentation] 呼吸性移動を考慮した線量分布による重粒子線呼吸同期照射の検討 (2012)
  • Author(s): 田代睦
  • Organizer: 第103回日本医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2012-04-14
• [Presentation] Technical approach and validation of respiratory-gated carbon-ion therapy for mobile organs at Gunma University (2011)
  • Author(s): M. Tashiro
  • Organizer: The Annual PTCOG50 meeting
  • Place of Presentation: Philadelphia(USA)
  • Year and Date: 2011-05-12
• [Presentation] 群馬大学重粒子線医学センターにおける呼吸同期照射に関する検討 (2011)
  • Author(s): 田代睦
  • Organizer: 第101回日本医学物理学会学術大会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2011-04-10
• [Presentation] Technical approach and validation of respiratory-gated carbon-ion therapy for mobile organs at Gunma University (2011)
  • Author(s): M. Tashiro, T. Ishii, J. Koya, R. Okada, Y. Kurosawa, K. Arai, S. Abe, H. Shimada, K. Yusa, K. Torikai, T. Kanai, S. Yamada, H. Kawamura, T. Ebara, T. Ohno, T. Nakano
  • Organizer: The Annual PTCOG 50 meeting
  • Place of Presentation: Philadelphia, USA
• [Presentation] 群馬大学重粒子線医学センターにおける呼吸同期照射に関する検討 (2011)
  • Author(s): 田代睦、石居隆義、小屋順一、岡田良介、黒澤裕司、遊佐顕、島田博文、鳥飼幸太、金井達明、山田聰、河村英将、江原威、大野達也、高橋健夫、中野隆史
  • Organizer: 第101回日本医学物理学会学術大会
  • Place of Presentation: 横浜
• [Presentation] 重粒子線治療における位置精度について ～治療計画および位置決めの現状と展望～
  • Author(s): 田代 睦
  • Organizer: 第47回 群馬放射線腫瘍研究会
  • Place of Presentation: 群馬県前橋市
  • Invited
• [Presentation] INVESTIGATION OF RESPIRATORY-GATED CARBON TREATMENT USING MOTION-INCLUDED DOSE DISTRIBUTION
  • Author(s): Mutsumi Tashiro
  • Organizer: The 31st Sapporo International Cancer Symposium, Advanced Radiation Therapy and Cancer Research
  • Place of Presentation: Sapporo, Hokkaido, Japan
• [Presentation] Investigation of Respiratory-Gated Carbon Treatment Planning Using Motion-Included Dose Distribution
  • Author(s): Mutsumi Tashiro
  • Organizer: 51st Annual Meeting of Particle Therapy Co-Operative Group (PTCOG51)
  • Place of Presentation: Seoul, Korea
• [Presentation] 呼吸性移動を考慮した線量分布による重粒子線呼吸同期照射の検討
  • Author(s): 田代 睦
  • Organizer: 第103回日本医学物理学会学術大会
  • Place of Presentation: 神奈川県横浜市