| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
For the purpose of the development of the objective evaluation method of the disease caused by aging or stress, I worked on the imaging study of the sigma-1 receptor in the brain. Out of my expectation, the newly developed compound, p-iodo-trans-decalinvesamicol (PIDV), was found to possess the high affinity and selectivity to sigma-2 receptor, not to sigma-1 receptor, in in vitro. The sigma-2 receptor is known to express in higher density in high proliferation potency human cancer cells, such as breast cancer. However, the clinically applicable sigma-2 receptor ligand is not developed yet. As a result of this study, I succeeded in developing the promising sigma-2 receptor imaging agent which enables the early image diagnosis of breast cancer.
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