Prediction of Targeted Therapy Outcome for Fatty Acid Synthase by Acetate PET

• Project/Area Number: 23791403
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: YOSHII Yukie 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (10397242)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 核医学(PETを含む) / 治療効果予測 / PET / 分子標的治療 / 事前治療効果予測 / 酢酸PET

Research Abstract

Here, we showed the method to predict FASN-targeted therapy outcome using acetate PET and presented mechanisms of FASN-targeted therapy to provide the treatment strategy of FASN-targeted therapy.

Research Products

• [Journal Article] Fatty acid synthase is a key target in multiple essential tumor functions of prostate cancer: uptake of radiolabeled acetate as a predictor of the targeted therapy outcome. (2013)
  • Author(s): Yoshii Y, Furukawa T, Oyama N, Hasegawa Y, Kiyono Y, Nishii R, Waki A, Tsuji AB, Sogawa C, Wakizaka H, Fukumura T, Yoshii H, Fujibayashi Y, Lewis JS, Saga T.
  • Journal Title: PLOS ONE Volume: 8 Issue: 5 Pages: e64570-e64570
  • DOI: 10.1371/journal.pone.0064570
  • Peer Reviewed
• [Journal Article] Fatty Acid Synthase Is a Key Target in Multiple Essential Tumor Functions of Prostate Cancer: Uptake of Radiolabeled Acetate as a Predictor of the Targeted Therapy Outcome (2013)
  • Author(s): Yoshii Y, Furukawa T, Oyama N, Hasegawa Y, Kiyono Y, Nishii R, Waki A, Tsuji AB, Sogawa C, Wakizaka H, Fukumura T, Yoshii H, Fujibayashi Y, Lewis JS, and Saga T
  • Journal Title: PLOS ONE Volume: in press
  • Peer Reviewed
• [Presentation] [1-11C]酢酸PETによる脂肪酸合成酵素標的がん制御治療の効果予測 (2012)
  • Author(s): 吉井幸恵、古川高子、大山伸幸、長谷川陽子、清野泰、西井龍一、辻厚至、脇坂秀克、藤林靖久、佐賀恒夫
  • Organizer: 第52回 日本核医学会
  • Place of Presentation: 札幌(北海道)
• [Presentation] Fatty acid synthase is a key target to suppress tumor multiple functions: [1-11C]acetate PET as a predictor of the targeted therapy outcome (2012)
  • Author(s): Yukie Yoshii, Takako Furukawa, Nobuyuki Oyama, Yoko Hasegawa, Yasushi Kiyono, Ryuichi Nishii, Atsushi Tsuji, Chizuru Sogawa, Hidekatsu Wakizaka, Hiroshi Yoshii, Yasuhisa Fujibayashi, Tsuneo Saga
  • Organizer: 2012 World Molecular Imaging Congress
  • Place of Presentation: Dublin, Ireland
• [Presentation] 酢酸PETによる脂肪酸合成酵素標的がん制御治療の効果予測:脂肪酸合成酵素の腫瘍増殖における役割に関する新知見 (2012)
  • Author(s): 吉井幸恵、古川高子、大山伸幸、長谷川陽子、清野泰、西井龍一、脇厚生、吉井裕、辻厚至、曽川千鶴、脇坂秀克、藤林靖久、佐賀恒夫
  • Organizer: 第7回 日本分子イメージング学会
  • Place of Presentation: 浜松(静岡)
• [Presentation] [1-11C]酢酸PETによる脂肪酸合成酵素標的がん制御治療の効果予測 (2012)
  • Author(s): 吉井幸恵、古川高子、大山伸幸、長谷川陽子、清野泰、西井龍一、辻厚至、脇坂秀克、藤林靖久、佐賀恒夫
  • Organizer: 第52回日本核医学会
  • Place of Presentation: 札幌
• [Presentation] Fatty acid synthase is a key target to suppress tumor multiple functions: [1-11C]acetate PET as a predictor of the targeted therapy outcome (2012)
  • Author(s): Yoshii Y, Furukawa T, Oyama N, YHasegawa Y, Kiyono Y, Nishii R, Tsuji AB, Sogawa C, Wakizaka H, Yoshii H, Fujibayashi Y, Saga T
  • Organizer: 2012 World Molecular Imaging Congress
  • Place of Presentation: Dublin, Ireland
• [Presentation] 酢酸PETによる脂肪酸合成酵素標的がん制御治療の効果予測:脂肪酸合成酵素の腫瘍増殖における役割に関する新知見 (2012)
  • Author(s): 吉井幸恵、古川高子、大山伸幸、長谷川陽子、清野泰、西井龍一、脇厚生、吉井裕、辻厚至、曽川千鶴、脇坂秀克、藤林靖久、佐賀恒夫
  • Organizer: 第7回 日本分子イメージング学会
  • Place of Presentation: 浜松
• [Remarks] 「脂肪酸合成を標的としたがん治療における新戦略 -PETを用い個別のがん治療効果を予測する方法を開発- 脂肪酸合成を妨げることががんの増殖・転移を抑える鍵となることも発見」平成25年6月1日
  • URL: http://www.nirs.go.jp/index.shtml