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Evaluation of segmental liver reserve using functional imaging technique.

Research Project

Project/Area Number 23791405
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionShinshu University

Principal Investigator

YAMADA Akira  信州大学, 医学部附属病院, 助教 (80419407)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords肝予備能 / 肝細胞特異性造影剤 / MRI / コンパートメントモデル / HUI / 肝機能 / 造影剤 / 肝切除 / 肝動脈化学塞栓療法 / 肝不全 / 画像
Research Abstract

We established a compartment model analysis of hepatocellular specific contrast agent, gadoxetic disodium using magnetic resonance (MR) imaging that can evaluate hepatic hemodynamics and function independently. Further more, we established Hepatocellular Uptake Index, HUI that is a quantitative index of hepatic reserve by simplification of the compartment model. HUI can be well correlated with indocyanine green (ICG) clearance test; further more, a segmental hepatic reserve can be evaluated by remnant HUI that can be derived from HUI.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (55 results)

All 2014 2013 2012 2011 Other

All Journal Article (11 results) (of which Peer Reviewed: 2 results) Presentation (42 results) (of which Invited: 12 results) Book (2 results)

  • [Journal Article] Gd-EOB-DTPA造影MRIによる定量的肝機能評価2013

    • Author(s)
      山田哲
    • Journal Title

      日独医報

      Volume: 58巻2号 Pages: 186-193

    • NAID

      120007100583

    • Related Report
      2013 Final Research Report
  • [Journal Article] 3D Radial VIBE2013

    • Author(s)
      山田哲(他5名)
    • Journal Title

      インナービジョン

      Volume: 28巻9号 Pages: 33-36

    • Related Report
      2013 Final Research Report
  • [Journal Article] MRI造影剤の薬物動態と臨床応用2013

    • Author(s)
      山田哲(他1名)
    • Journal Title

      画像診断

      Volume: 33巻2号 Pages: 242-253

    • Related Report
      2013 Final Research Report
  • [Journal Article] 3D Radial VIBE2013

    • Author(s)
      山田 哲
    • Journal Title

      インナービジョン

      Volume: 28 Pages: 33-36

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Gd-EOB-DTPA造影MRIによる定量的肝機能評価2013

    • Author(s)
      山田 哲
    • Journal Title

      日独医報

      Volume: 58 Pages: 186-193

    • NAID

      120007100583

    • Related Report
      2013 Annual Research Report
  • [Journal Article] MRI造影剤の薬物動態と臨床応用2013

    • Author(s)
      山田 哲
    • Journal Title

      画像診断

      Volume: 33 Pages: 242-254

    • Related Report
      2012 Research-status Report
  • [Journal Article] Quantitative evaluation of liver function within MR imaging2012

    • Author(s)
      Yamada A.
    • Journal Title

      OMICS J Radiology 2012

      Volume: 1

    • NAID

      120007100584

    • Related Report
      2013 Final Research Report
  • [Journal Article] Quantitative evaluation of liver function with use of gadoxetate disodium-enhanced MR imaging2011

    • Author(s)
      Yamada A(他6名)
    • Journal Title

      Radiology 2011

      Volume: 260 Pages: 727-733

    • NAID

      120007100585

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] RIによる肝予備能の診断-肝胆道系特異性造影剤の有用性2011

    • Author(s)
      山田哲(他4名)
    • Journal Title

      肝胆膵画像

      Volume: 13巻1号 Pages: 65-70

    • Related Report
      2013 Final Research Report
  • [Journal Article] Quantitative evaluation of liver function with use of gadoxetate disodium-enhanced MR imaging.2011

    • Author(s)
      Yamada A, Hara T, Li F, Fujinaga Y, Ueda K, Kadoya M, Doi K.
    • Journal Title

      Radiology

      Volume: 260 Issue: 3 Pages: 727-733

    • DOI

      10.1148/radiol.11100586

    • NAID

      120007100585

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] MRIによる肝予備能の診断-肝胆道系特異性造影剤の有用性2011

    • Author(s)
      山田 哲,上田和彦,藤永康成,黒住昌弘,角谷眞澄
    • Journal Title

      肝胆膵画像

      Volume: 13 Pages: 65-70

    • Related Report
      2011 Research-status Report
  • [Presentation] 肝血流動態・機能の定量的画像解析2014

    • Author(s)
      山田哲, 他
    • Organizer
      第55回信州放射線談話会
    • Place of Presentation
      長野
    • Year and Date
      2014-06-24
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 肝血流動態・機能の定量的画像解析2014

    • Author(s)
      山田哲, 他
    • Organizer
      広島画像診断講演会
    • Place of Presentation
      広島
    • Year and Date
      2014-05-09
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] コンパートメントモデル解析における血流動態定量精度の向上 : 入力補正アルゴリズムの利用2014

    • Author(s)
      山田哲, 他
    • Organizer
      第73回日本医学放射線学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-04-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Quantitative evaluation of segmental liver reserve with use of gadoxetate disodium-enhanced MR imaging2013

    • Author(s)
      Yamada A, et al
    • Organizer
      65th Annual congress of the Korean surgical society
    • Place of Presentation
      Seoul
    • Year and Date
      2013-11-22
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] EOB-MRIによる部分肝機能評価2013

    • Author(s)
      山田哲, 他
    • Organizer
      JDDW2013
    • Place of Presentation
      東京(ランチョンセミナー)
    • Year and Date
      2013-10-09
    • Related Report
      2013 Final Research Report
  • [Presentation] Gd-EOB-DTPA造影MRIを用いた定量的肝細胞取込み能評価 : 薬物動態解析と静的信号強度解析の比較2013

    • Author(s)
      山田哲, 他
    • Organizer
      第41回日本磁気共鳴医学会大会
    • Place of Presentation
      徳島
    • Year and Date
      2013-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Radial VIBE法Gd-EOB-DTPA造影MRIの非線形コンパートメントモデル解析による肝細胞癌の分化度診断2013

    • Author(s)
      山田哲, 他
    • Organizer
      第49回日本肝癌研究会
    • Place of Presentation
      東京(シンポジウム)
    • Year and Date
      2013-07-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Quantitative evaluation of hepatocellular uptake function with use of gadolinium disodium-enhanced MR imaging : comparison of dynamic pharmacokinetic analysis and static signal intensity analysis2013

    • Author(s)
      Yamada A, et al
    • Organizer
      ESGAR
    • Place of Presentation
      Barcelona
    • Year and Date
      2013-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝癌診療におけるEOB造影MRIの有用性2013

    • Author(s)
      山田哲, 他
    • Organizer
      先端医療センター映像診療科研修会
    • Place of Presentation
      神戸
    • Year and Date
      2013-04-19
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Radial VIBE法Gd-EOB-DTPA造影MRIの非線形2-コンパートメントモデル解析による肝線維化評価2013

    • Author(s)
      山田哲, 他
    • Organizer
      第72回日本医学放射線学会学術集会
    • Place of Presentation
      横浜(シンポジウム)
    • Year and Date
      2013-04-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝MR造影剤の基礎と臨床2012

    • Author(s)
      山田哲, 他
    • Organizer
      第40回日本磁気共鳴医学会大会
    • Place of Presentation
      京都(教育講演)
    • Year and Date
      2012-09-06
    • Related Report
      2013 Final Research Report
  • [Presentation] EOB造影MRIの基礎と臨床2012

    • Author(s)
      山田哲, 他
    • Organizer
      第24回新潟MR画像研究会
    • Place of Presentation
      新潟(教育講演)
    • Year and Date
      2012-09-01
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝動脈造影下CT(CTHA)を用いた腫瘍栄養血管同定支援システムの開発2012

    • Author(s)
      山田哲, 他
    • Organizer
      第71回日本医学放射線学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-04-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝動脈造影下CT(CTHA)を用いた腫瘍栄養血管同定支援システムの開発2012

    • Author(s)
      山田哲, 他
    • Organizer
      第18回肝血流動態イメージ研究会
    • Place of Presentation
      神戸
    • Year and Date
      2012-01-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝動脈造影下CT(CTHA)を用いた腫瘍栄養血管同定支援システムの開発2012

    • Author(s)
      山田 哲
    • Organizer
      第18回肝血流動態イメージ研究会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Related Report
      2011 Research-status Report
  • [Presentation] Computerized Estimation of Segmental Liver Reserve after Transcatheter Arterial Chemoembolization by Use of Gadoxetate Disodium-enhanced MR imaging2011

    • Author(s)
      Yamada A, et al
    • Organizer
      RSNA
    • Place of Presentation
      Chicago
    • Year and Date
      2011-11-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体機能の画像診断2011

    • Author(s)
      山田哲, 他
    • Organizer
      第39回日本放射線技術学会秋季学術大会画像分科会
    • Place of Presentation
      神戸(シンポジウム)
    • Year and Date
      2011-10-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝細胞癌診療におけるEOB造影MRIの有用性・留意点・新たな可能性2011

    • Author(s)
      山田哲, 他
    • Organizer
      第47回日本医学放射線学会秋季臨床大会
    • Place of Presentation
      下関(ランチョンセミナー)
    • Year and Date
      2011-10-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Gadxetate Disodium造影MRIおよび肝動脈造影下CTを用いた肝動脈動注塞栓療法後部分肝予備能の定量的推定法2011

    • Author(s)
      山田哲, 他
    • Organizer
      第6回肝癌治療シミュレーション研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝動脈造影下CT(CTHA)を用いた腫瘍栄養血管同定支援システムの開発2011

    • Author(s)
      山田哲, 他
    • Organizer
      第47回日本肝癌研究会
    • Place of Presentation
      静岡(シンポジウム)
    • Year and Date
      2011-07-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 肝細胞癌診療におけるEOB造影MRIの有用性・留意点・新たな可能性2011

    • Author(s)
      山田 哲
    • Organizer
      第47回日本医学放射線学会秋季臨床大会(招待講演)
    • Place of Presentation
      海峡メッセ下関(下関)
    • Related Report
      2011 Research-status Report
  • [Presentation] 生体機能の画像診断2011

    • Author(s)
      山田 哲
    • Organizer
      第39回日本放射線技術学会秋季学術大会画像分科会(招待講演)
    • Place of Presentation
      神戸国際会議場(神戸)
    • Related Report
      2011 Research-status Report
  • [Presentation] 肝動脈造影下CT(CTHA)を用いた腫瘍栄養血管同定支援システムの開発2011

    • Author(s)
      山田 哲
    • Organizer
      第47回日本肝癌研究会
    • Place of Presentation
      静岡県コンベンションセンター(静岡)
    • Related Report
      2011 Research-status Report
  • [Presentation] Gadxetate Disodium造影MRIおよび肝動脈造影下CTを用いた肝動脈動注塞栓療法後部分肝予備能の定量的推定法2011

    • Author(s)
      山田 哲
    • Organizer
      第6回肝癌治療シミュレーション研究会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2011 Research-status Report
  • [Presentation] Computerized Estimation of Segmental Liver Reserve after Transcatheter Arterial Chemoembolization by Use of Gadoxetate Disodium-enhanced MR imaging.2011

    • Author(s)
      Akira Yamada
    • Organizer
      RSNA 97th Scientific Assembly and Annual Meeting
    • Place of Presentation
      McCormick Place, Chicago, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] Radial VIBE法Gd-EOB-DTPA造影MRIの非線形2-コンパートメントモデル解析による肝線維化評価

    • Author(s)
      山田 哲
    • Organizer
      第72回日本医学放射線学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report 2012 Research-status Report
  • [Presentation] 肝癌診療におけるEOB造影MRIの有用性

    • Author(s)
      山田 哲
    • Organizer
      先端医療センターセミナー
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Quantitative evaluation of hepatocellular uptake function with use of gadolinium disodium-enhanced MR imaging: comparison of dynamic pharmacokinetic analysis and static signal intensity analysis

    • Author(s)
      Akira Yamada
    • Organizer
      ESGAR
    • Place of Presentation
      Barcelona
    • Related Report
      2013 Annual Research Report
  • [Presentation] Radial VIBE法Gd-EOB-DTPA造影MRIの非線形コンパートメントモデル解析による肝細胞癌の分化度診断

    • Author(s)
      山田 哲
    • Organizer
      第49回日本肝癌研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Gd-EOB-DTPA造影MRIを用いた定量的肝細胞取込み能評価:薬物動態解析と静的信号強度解析の比較

    • Author(s)
      山田 哲
    • Organizer
      第41回日本磁気共鳴医学会大会
    • Place of Presentation
      徳島
    • Related Report
      2013 Annual Research Report
  • [Presentation] EOB-MRIによる部分肝機能評価

    • Author(s)
      山田 哲
    • Organizer
      肝臓学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Quantitative evaluation of segmental liver reserve with use of gadoxetate disodium-enhanced MR imaging

    • Author(s)
      Akira Yamada
    • Organizer
      65th Annual congress of the Korean surgical society
    • Place of Presentation
      Seoul
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Gd-EOB-DTPA造影MRIによる肝線維化評価:信号強度およびテクスチャー解析による検討

    • Author(s)
      山田 哲
    • Organizer
      第1回びまん性肝疾患の画像研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] コンパートメントモデル解析における血流動態定量精度の向上:入力補正アルゴリズムの利用

    • Author(s)
      山田 哲
    • Organizer
      第73回日本医学放射線学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肝血流動態・機能の定量的画像解析

    • Author(s)
      山田 哲
    • Organizer
      広島画像診断講演会
    • Place of Presentation
      広島
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 肝血流動態・機能の定量的画像解析

    • Author(s)
      山田 哲
    • Organizer
      信州放射線談話会
    • Place of Presentation
      長野
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] EOB造影MRIの基礎と臨床

    • Author(s)
      山田 哲
    • Organizer
      第24回新潟MR画像研究会
    • Place of Presentation
      新潟
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 肝MR造影剤の基礎と臨床

    • Author(s)
      山田 哲
    • Organizer
      第40回日本磁気共鳴医学会大会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Quantitative Evaluation of Postoperative Liver Reserve with Use of Gadoxetate Disodium-enhanced MR Imaging: Comparison with 99mTc-galactosyl Serum Albumin Scintigraphy

    • Author(s)
      柳澤 新
    • Organizer
      RSNA2012
    • Place of Presentation
      Chicago, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] 肝癌診療におけるEOB造影MRIの有用性

    • Author(s)
      山田 哲
    • Organizer
      先端医療センターカンファランス
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Quantitative evaluation of hepatocellular uptake function with use of gadolinium disodium-enhanced MR imaging: comparison of dynamic pharmacokinetic analysis and static signal intensity analysis

    • Author(s)
      山田 哲
    • Organizer
      ESGAR2013
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2012 Research-status Report
  • [Presentation] 肝動脈造影下CT(CTHA)を用いた腫瘍栄養血管同定支援システムの開発

    • Author(s)
      山田 哲
    • Organizer
      第71回日本医学放射線学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Book] Quantitative evaluation of liver function within MR imaging, Abdomen and thoracic imaging : an engineering & clinical perspective2013

    • Author(s)
      Yamada A.
    • Publisher
      Springer
    • Related Report
      2013 Final Research Report
  • [Book] Abdomen and thoracic imaging: an engineering & clinical perspective2013

    • Author(s)
      Akira Yamada
    • Publisher
      Springer
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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