Diagnostic imaging of atherosclerosis using mannan-coated superparamagnetic iron oxide particles
| Project/Area Number |
23791407
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
OTANI Hideji 滋賀医科大学, 医学部, 助教 (70510270)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 微小超常磁性酸化鉄ナノ粒子 / MRI造影剤 / 動脈硬化 |
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| Research Abstract |
We performed comparative study of mannan-coated ultrasmall superparamagnetic iron oxide(mannan-coated USPIO), mannandextran-coated USPIO, and dextran-coated USPIO in the uptake bythe atherosclerotic wall using MRI and histology. Our histological and imaging analyses showed that mannan-coated USPIO and mannandextran-coated USPIO were taken up to a greater degree than dextran-coated USPIO. We suggest that mannan-coated particles are useful for the atherosclerotic imaging.
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Report
(3 results)
Research Products
(3 results)
