Establishment of procedures in stereotactic body radiotherapy for liver cancer

• Project/Area Number: 23791409
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: MATSUO Yukinori 京都大学, 医学(系)研究科(研究院), 講師 (80456897)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 肝臓癌 / 放射線治療 / 体幹部定位放射線治療

Research Abstract

A treatment flow in stereotactic body radiotherapy (SBRT) for liver cancer has been established thorough the present research. The flow includes insertion of a fiducial marker, optimal conditions for simulation CT, treatment planning and dose calculation, and dynamic tumor tracking irradiation. The present research adds a treatment option of SBRT to liver cancer. That can play an important role in cancer treatment in Japan. However, this research could not provide optimal procedures in follow-up after liver SBRT, and future research might be warranted.

Research Products

• [Journal Article] The Impact of Abdominal Compression on Outcome in Patients Treated with Stereotactic Body Radiotherapy for Primary Lung Cancer. (2014)
  • Author(s): Mampuya WA, Matsuo Y, Ueki N, Nakamura M, Mukumoto N, Nakamura A, Iizuka Y, Kishi T, Mizowaki T, Hiraoka M.
  • Journal Title: J Radiat Res Volume: 印刷中 Issue: 5 Pages: 934-9
  • DOI: 10.1093/jrr/rru028
  • NAID: 120005512252
  • Peer Reviewed / Open Access
• [Journal Article] Intra- and interfractional variations in geometric arrangement between lung tumours and implanted markers (2014)
  • Author(s): Ueki N, Matsuo Y, Nakamura M, et al.
  • Journal Title: Radiother Oncol Volume: (in press) Issue: 3 Pages: 523-8
  • DOI: 10.1016/j.radonc.2014.01.014
  • NAID: 120005439548
  • Peer Reviewed
• [Journal Article] 肝腫瘍に対するリアルタイムモニタリング下動体追尾照射の初期経験 (2014)
  • Author(s): 飯塚裕介,松尾幸憲,中村光宏, et al.
  • Journal Title: 定位的放射線治療 Volume: 18 Pages: 9-16
• [Journal Article] Differences in dose-volumetric data between the analytical anisotropic algorithm and the x-ray voxel Monte Carlo algorithm in stereotactic body radiation therapy for lung cancer (2013)
  • Author(s): Mampuya WA, Matsuo Y, Nakamura A, Nakamura M, Mukumoto N, Miyabe Y, Narabayashi M, Sakanaka K, Mizowaki T, Hiraoka M.
  • Journal Title: Med Dosim. Volume: 38 Issue: 1 Pages: 95-9
  • DOI: 10.1016/j.meddos.2012.07.007
  • Peer Reviewed
• [Journal Article] Interfraction variation in lung tumor position with abdominal compression during stereotactic body radiotherapy. (2013)
  • Author(s): Mampuya WA, Nakamura M, Matsuo Y, Ueki N, Iizuka Y, Fujimoto T, Yano S, Monzen H, Mizowaki T, Hiraoka M
  • Journal Title: Med Phys Volume: 40 Issue: 9 Pages: 91718-91718
  • DOI: 10.1118/1.4819940
  • Peer Reviewed
• [Journal Article] Differences in the dose-volume metrics with heterogeneity correction status and its influence on local control in stereotactic body radiation therapy for lung cancer. (2013)
  • Author(s): Ueki N, Matsuo Y, Shibuya K, Nakamura M, Narabayashi M, Sakanaka K,Norihisa Y, Mizowaki T, Hiraoka M
  • Journal Title: J Radiat Res Volume: 54(2) Issue: 2 Pages: 337-343
  • DOI: 10.1093/jrr/rrs084
  • NAID: 120005244225
  • Peer Reviewed
• [Journal Article] Multi-institutional comparison of treatment planning using stereotactic ablative body radiotherapy for hepatocellular carcinoma -- benchmark for a prospective multi-institutional study. (2013)
  • Author(s): Eriguchi T, Takeda A, Oku Y, Ishikura S, Kimura T, Ozawa S, Nakashima T, Matsuo Y, Nakamura M, Matsumoto Y, Yamazaki S, Sanuki N, Ito Y.
  • Journal Title: Radiat Oncol Volume: 8 Issue: 1 Pages: 113-113
  • DOI: 10.1186/1748-717x-8-113
  • Peer Reviewed
• [Journal Article] Interfractional dose variations in the stomach and the bowels during breath-hold intensity-modulated radiotherapy for pancreatic cancer: implications for a dose-escalation strategy. (2013)
  • Author(s): Nakamura A, Shibuya K, Nakamura M, Matsuo Y, Shiinoki T, Nakata M, Mizowaki T, Hiraoka M
  • Journal Title: Medical Physics Volume: 40(2) Issue: 2 Pages: 1217011-9
  • DOI: 10.1118/1.4773033
  • Peer Reviewed
• [Journal Article] Evaluation of 4D dose to a moving target with Monte Carlo dose calculation in stereotactic body radiotherapy for lung cancer (2013)
  • Author(s): Matsugi K, Nakamura M, Miyabe Y, Yamauchi C, Matsuo Y, Mizowaki T, Hiraoka M.
  • Journal Title: Radiol Phys Technol. Volume: 6 Issue: 1 Pages: 233-40
  • DOI: 10.1007/s12194-012-0193-y
  • Peer Reviewed
• [Journal Article] Huidelines for respiratory motion management in radiation therapy (2012)
  • Author(s): Y. Matsuo, H. Onishi, K. Nakagawa, M. Nakamura, T. Ariji, Y. Kumazaki, M. Shimbo, N. Tohyama, T. Nishio, M. Okumura, H. Shirato, M. Hiraoka
  • Journal Title: J. Rad. Res. Volume: - Issue: 3 Pages: 561-8
  • DOI: 10.1093/jrr/rrs122
  • Peer Reviewed
• [Journal Article] Preliminary Report of Late Recurrences, at 5 Years or More, after Stereotactic Body Radiation Therapy for Non-small Cell Lung Cancer (2012)
  • Author(s): Matsuo Y, Shibuya K, Nagata Y, Norihisa Y, Narabayashi M, Sakanaka K, Ueki N, Mizowaki T, Hiraoka M.
  • Journal Title: J Thorac Oncol Volume: 7 Issue: 2 Pages: 453-456
  • DOI: 10.1097/jto.0b013e31823c5b29
  • Peer Reviewed
• [Journal Article] Dose-volume metrics associated with radiation pneumonitis after stereotactic body radiation therapy for lung cancer. (2012)
  • Author(s): Matsuo Y, Shibuya K, Nakamura M, Narabayashi M, Sakanaka K, Ueki N, Miyagi K, Norihisa Y, Mizowaki T, Nagata Y, Hiraoka M.
  • Journal Title: Int J Radiat Oncol Biol Phys. Volume: 83(4) Issue: 4 Pages: e545-e549
  • DOI: 10.1016/j.ijrobp.2012.01.018
  • NAID: 120004367786
  • Peer Reviewed
• [Journal Article] Dosimetric evaluation of the impacts of different heterogeneity correction algorithms on target doses in stereotactic body radiation therapy for lung tumors. (2012)
  • Author(s): Narabayashi M, Mizowaki T, Matsuo Y, Nakamura M, Takayama K, Norihisa Y, Sakanaka K, Hiraoka M.
  • Journal Title: J Radiat Res Volume: 53(5) Issue: 5 Pages: 777-84
  • DOI: 10.1093/jrr/rrs026
  • Peer Reviewed
• [Journal Article] Hyperfractionated Irradiation with 3 Cycles of Induction Chemotherapy in Stage IIIA-N2 Lung Cancer. (2012)
  • Author(s): Chen F, Okubo K, Sonobe M, et al.
  • Journal Title: World J Surg. Volume: 36 Issue: 12 Pages: 2858-64
  • DOI: 10.1007/s00268-012-1747-1
  • Peer Reviewed
• [Journal Article] Optimization of the X-ray monitoring angle for creating a correlation model between internal and external respiratory signals. (2012)
  • Author(s): M. Akimoto, M. Nakamura, N. Mukumoto, M. Yamada, N. Ueki, Y.Matsuo, A. Sawada, T. Mizowaki, M. Kokubo, M. Hiraoka
  • Journal Title: Medical Physics Volume: 39 Issue: 10 Pages: 6309-6315
  • DOI: 10.1118/1.4754648
  • Peer Reviewed
• [Journal Article] Interfractional dose variations in intensity-modulated radiotherapy with Breath-hold for pancreatic cancer. (2012)
  • Author(s): Nakamura M, Shibuya K, Nakamura A, Shiinoki T, Matsuo Y, Nakata M, Sawada A, Mizowaki T, Hiraoka M.
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 82(5) Issue: 5 Pages: 1619-26
  • DOI: 10.1016/j.ijrobp.2011.01.050
  • Peer Reviewed
• [Journal Article] 肺がんの治療－早期肺がんに対する体幹部定位放射線治療. (2012)
  • Author(s): 松尾幸憲
  • Journal Title: Mebio Volume: 29 Pages: 46-51
• [Journal Article] 京都大学がん診療部における局所進行喉頭癌に対する喉頭温存治療の取り組み. (2012)
  • Author(s): 平野滋, 北村守正, 楯谷一郎, et al.
  • Journal Title: 頭頸部癌 Volume: 38 Pages: 447-53
  • Peer Reviewed
• [Journal Article] 進行肝細胞癌に伴う下大静脈腫瘍栓,門脈腫瘍栓に対する放射線治療の有効性 (2012)
  • Author(s): 小山幸法, 波多野悦朗, 田浦康二朗, et al.
  • Journal Title: 肝臓 Volume: 53 Pages: 486-93
  • Peer Reviewed
• [Journal Article] Analysis of dosimetric parameters associated with acute gastrointestinal toxicity and upper gastrointestinal bleeding in locally advanced pancreatic cancer patients treated with gemcitabine-based concurrent chemoradiotherapy. (2012)
  • Author(s): Nakamura A, Shibuya K, Matsuo Y, Nakamura M, Shiinoki T, Mizowaki T, Hiraoka M.
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 84(2) Issue: 2 Pages: 369-75
  • DOI: 10.1016/j.ijrobp.2011.12.026
  • Peer Reviewed
• [Journal Article] Experimental valdation of heterogeneity-corrected dose-volume prescription on respiratory-averaged CT images in stereotactic body radiotherapy for moving tumors. (2012)
  • Author(s): Nakamura M, Miyabe Y, Matsuo Y, Kamomae K, Nakata M, Yano S, Sawada A, Mizowaki T, Hiraoka M.
  • Journal Title: Med Dosim. Volume: 37 Issue: 1 Pages: 20-25
  • DOI: 10.1016/j.meddos.2010.12.007
  • Peer Reviewed
• [Journal Article] Dosimetric investigation of breath-hold intensity-modulated radiotherapy for pancreatic cancer. (2012)
  • Author(s): Nakamura M, Kishimoto S, Iwamura K, Shiinoki T, Nakamura A, Matsuo Y, Shibuya K, Hiraoka M.
  • Journal Title: Med Phys. Volume: 39 Issue: 1 Pages: 48-54
  • DOI: 10.1118/1.3668314
  • Peer Reviewed
• [Journal Article] Prognostic factors in stereotactic body radiotherapy for non-small-cell lung cancer. (2011)
  • Author(s): Matsuo Y, Shibuya K, Nagata Y, Takayama K, Norihisa Y, Mizowaki T, Narabayashi M, Sakanaka K, Hiraoka M
  • Journal Title: Int J Radiat Oncol Biol Phys. Volume: 79(4) Issue: 4 Pages: 1104-11
  • DOI: 10.1016/j.ijrobp.2009.12.022
  • Peer Reviewed
• [Journal Article] Detailed dosimetric evaluation of intensity-modulated radiation therapy plans created for stage C prostate cancer based on a planning protocol (2011)
  • Author(s): Norihisa Y, Mizowaki T, Takayama K, Miyabe Y, Matsugi K, Matsuo Y, Narabayashi M, Sakanaka K, Nakamura A, Nagata Y, Hiraoka M.
  • Journal Title: Int J Clin Oncol. Volume: (印刷中) Issue: 5 Pages: 505-511
  • DOI: 10.1007/s10147-011-0324-1
  • NAID: 10031144339
  • Peer Reviewed
• [Journal Article] Positioning accuracy of a new image-guided radiotherapy system (2011)
  • Author(s): Miyabe Y, Sawada A, Takayama K, Kaneko S, Mizowaki T, Kokubo M, Hiraoka M.
  • Journal Title: Med. Phys. Volume: 38 Issue: 5 Pages: 2535-2541
  • DOI: 10.1016/j.ijrobp.2010.05.046
  • URL: http://online.medphys.org/resource/1/mphya6/v38/i5/p2535_s1
  • Peer Reviewed
• [Journal Article] Phase II study of radiation therapy combined with weekly low-dose gemcitabine for locally advanced, unresectable pancreatic cancer (2011)
  • Author(s): Shibuya K, Oya N, Fujii T, Doi R, Nakamura A, Matsuo Y, Mitsumori M, Hiraoka M
  • Journal Title: Am J Clin Oncol Volume: 134 Issue: 2 Pages: 115-119
  • DOI: 10.1097/coc.0b013e3181c4c7a8
  • Peer Reviewed
• [Journal Article] Interfractional reproducibility in pancreatic position based on four-dimensional computed tomography. (2011)
  • Author(s): Shiinoki T, Shibuya K, Nakamura M, Nakamura A, Matsuo Y, Nakata M, Sawada A, Mizowaki T, Itoh A and Hiraoka M.
  • Journal Title: Int J Radiat Oncol Biol Phys. Volume: 80(5) Issue: 5 Pages: 1567-1572
  • DOI: 10.1016/j.ijrobp.2010.10.020
  • Peer Reviewed
• [Presentation] Dynamic Tumor Tracking Irradiation with Real-time Monitoring using Vero4DRT (MHI-TM2000) (2013)
  • Author(s): Matsuo Y.
  • Organizer: GAP 2013 Conference
  • Place of Presentation: MD Anderson Cancer Center, Houston, TX, USA
  • Year and Date: 2013-04-03
• [Presentation] Vero4DRTを用いたリアルタイムモニタリング下の動体追尾放射線治療 (2013)
  • Author(s): 松尾幸憲
  • Organizer: 第26回日本高精度放射線外部照射研究会
  • Place of Presentation: 京都テルサ、京都
  • Year and Date: 2013-02-23
• [Presentation] Stereotactic Body Radiotherapy for the Lung (2013)
  • Author(s): Matsuo Y.
  • Organizer: 37th Annual MD Anderson Radiation Oncology/Gilbert H. Fletcher Society Meeting
  • Place of Presentation: The Westin Miyako Kyoto, Kyoto, Japan
• [Presentation] Dynamic Tumor Tracking Radiotherapy with Real-Time Monitoring using Vero4DRT (2013)
  • Author(s): Matsuo Y, Ueki N, Takayama K, et al.
  • Organizer: 15th World Conference on Lung Cancer
  • Place of Presentation: Sydney, Australia
• [Presentation] Dynamic Tumor Tracking Radiotherapy with Real-Time Monitoring using Vero4DRT. (2013)
  • Author(s): Matsuo Y, Ueki N, Takayama K, Nakamura M, Miyabe Y, Tanabe H, Kaneko S, Mizowaki T, Monzen H, Sawada A, Kokubo M, Hiraoka M
  • Organizer: 15th World Conference on Lung Cancer.
  • Place of Presentation: Sydney, Australia
• [Presentation] Dynamic Tumor Tracking Irradiation with Real-time Monitoring using Vero4DRT (MHI-TM2000) (2012)
  • Author(s): Matsuo Y, Sawada A, Ueki N, et al.
  • Organizer: The 4th Japan-Korea-China Trilateral Symposium on Radiation Oncology
  • Place of Presentation: 東京国際フォーラム、東京
  • Year and Date: 2012-11-23
• [Presentation] Image-guided Radiotherapy and Dynamic Tumor Tracking with Real-time Monitoring using Vero4DRT (MHI-TM2000) (2012)
  • Author(s): Matsuo Y.
  • Organizer: The 6th S. Takahashi Memorial Symposium and the 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: 広島国際会議場、広島, Japan
• [Presentation] Dynamic Tumor Tracking with Real-time Monitoring using a Gimbaled Linac of Vero4DRT (MHI-TM2000) (2012)
  • Author(s): Matsuo Y, Hiraoka M.
  • Organizer: EPI2k12. Four Points by Sheraton, Daring Harbour, Sydney, Australia
  • Place of Presentation: Australia
• [Presentation] 肺癌定位放射線治療における呼吸性移動対策 : MHI-TM2000(Vero)を用いた動体追尾照射を中心にシンポジウム2「高精度放射線治療の現状と今後の展望」 (2012)
  • Author(s): 松尾幸憲
  • Organizer: 第24回日本高精度放射線外部照射研究会
  • Place of Presentation: パシフィコ横浜
• [Presentation] An Initial Experience of Dynamic Tumor Tracking Irradiation with Real-time Monitoring using Vero4DRT (MHI-TM2000) (2012)
  • Author(s): Matsuo Y, Sawada A, Ueki N, et al.
  • Organizer: ESTRO 31. CCIB, Barcelona, Spain
  • Place of Presentation: Spain
• [Presentation] Impact of Overall Treatment Time on Local Control after Stereotactic Body Radiation Therapy for Lung Cancer (2012)
  • Author(s): Matsuo Yukinori
  • Organizer: ASTRO's 54th Annual Meeting
  • Place of Presentation: ボストン
• [Presentation] 当院における肝定位放射線治療の初期経験 (2012)
  • Author(s): 宮城 健、松尾 幸憲、植木 奈美、吉村 通央、板坂 聡、溝脇 尚志、平岡 眞寛
  • Organizer: 第24回日本高精度放射線外部照射研究会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] 肺癌定位放射線治療における呼吸性移動対策: MHI-TM2000 (Vero) を用いた動体追尾照射を中心に (2012)
  • Author(s): 松尾 幸憲
  • Organizer: 第24回高精度外部照射研究会(招待講演)
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] Gimbaled linac adaptation (2012)
  • Author(s): Matsuo Y
  • Organizer: 12th International Conference on Electronic PATIENT Imaging(招待講演)
  • Place of Presentation: Four Points by Sheraton Sydney, Darling Harbour（シドニー、オーストラリア）
• [Presentation] Dose-Volume Analysis in a Phase II Study of Stereotactic Body Radiation Therapy for cT1N0M0 Non-small Cell Lung Cancer (JCOG0403): Impact of Dose Calculation Algorithm with Heterogeneity Correction on Local Control in Operable Patients (2011)
  • Author(s): Yukinori Matsuo, Satoshi Ishikura, Taro Shibata, Masaki Kokubo, Katsuyuki Karasawa, Takuyo Kozuka, Kunihiko Tateoka, Shigeo Anai, Yasushi Nagata, Masahiro Hiraoka
  • Organizer: ASTRO 53rd Meeting
  • Place of Presentation: Miami Beach Convention Center（マイアミ、米国）
• [Presentation] 原発性肺癌に対する体幹部定位放射線治療における総治療期間の影響について (2011)
  • Author(s): 松尾幸憲、澁谷景子、植木奈美、坂中克行、楢林正流、則久佳毅、矢野慎輔、中田 学、溝脇尚志、平岡真寛
  • Organizer: 日本放射線腫瘍学会第24回学術大会
  • Place of Presentation: 神戸ポートピアホテル（神戸市）
• [Presentation] 肺癌に対する体幹部定位放射線治療５年以上経過後の再発例に関する検討 (2011)
  • Author(s): 松尾 幸憲, 澁谷 景子, 植木 奈美, 平岡 真寛
  • Organizer: 第52回日本肺癌学会総会
  • Place of Presentation: 大阪国際会議場（大阪市）
• [Presentation] Dynamic Tumor Tracking Irradiation with Real-time Monitoring using Vero4DRT (MHI-TM2000)
  • Author(s): Matsuo, Yukinori
  • Organizer: GAP 2013 Conference
  • Place of Presentation: MD Anderson Cancer Center, Houston, TX, USA
• [Presentation] 肺がんおよび肝がんに対する定位放射線療法
  • Author(s): 松尾幸憲
  • Organizer: 滋賀県立成人病センター 第40回がん診療セミナー
  • Place of Presentation: 滋賀県立成人病センター、守山市
  • Invited
• [Presentation] Image-guided Radiotherapy and Dynamic Tumor Tracking with Real-time Monitoring using Vero4DRT (MHI-TM2000)
  • Author(s): Matsuo Yukinori
  • Organizer: The 6th S. Takahashi Memorial Symposium and the 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: 広島国際会議場、広島
  • Invited
• [Presentation] Dynamic Tumor Tracking Irradiation with Real-time Monitoring using Vero4DRT (MHI-TM2000)
  • Author(s): Matsuo Yukinori
  • Organizer: The 4th Japan-Korea-China Trilateral Symposium on Radiation Oncology
  • Place of Presentation: 東京国際フォーラム、東京
• [Presentation] An Initial Experience of Dynamic Tumor Tracking Irradiation with Real-time Monitoring using Vero4DRT (MHI-TM2000)
  • Author(s): Matsuo Yukinori
  • Organizer: ESTRO 31
  • Place of Presentation: CCIB, Barcelona, Spain
• [Presentation] Vero4DRTを用いた リアルタイムモニタリング下の動体追尾放射線治療
  • Author(s): 松尾幸憲
  • Organizer: 第26回日本高精度放射線外部照射研究会
  • Place of Presentation: 京都テルサ、京都
  • Invited
• [Presentation] MHI-TM2000（Vero）を用いたリアルタイムモニタリング動体追尾照射の初期経験
  • Author(s): 松尾幸憲
  • Organizer: 第71回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜、横浜
• [Book] 体幹部定位放射線治療後の晩期再発. 日本臨牀. 2013;71(増刊号6) (2013)
  • Author(s): 松尾幸憲
  • Publisher: 日本臨牀
• [Book] Stereotactic Body Radiotherapy for the Lung, De Salles AAF, Gorgulho A, Agazaryan N, et al., eds. Shaped Beam Radiosurgery. (2011)
  • Author(s): Matsuo Y, Shibuya K, Narabayashi M, Hiraoka M
  • Publisher: Springer Berlin Heidelberg
• [Book] Shaped Beam Radiosurgery (2011)
  • Author(s): Matsuo Y, Shibuya K, Narabayashi M, Hiraoka M
  • Publisher: Springer Berlin Heidelberg