Software development and three-dimensional quantitative analysis to establish multidisciplinary diagnosis for pulmonary adenocarcinoma

• Project/Area Number: 23791417
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Osaka University
• Principal Investigator: YANAGAWA Masahiro 大阪大学, 医学系研究科, 助教 (00546872)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 肺腺癌 / 病理学的国際分類 / 病理学的浸潤部 / 病理学的非浸潤部 / すりガラス成分 / 3 次元画像解析 / 病理学的国際新分類 / 3次元画像解析 / 日本

Research Abstract

A custom-developed software can segment solid portion and ground-glass opacity (GGO) using the previously-reported threshold selection method for segmenting gray-level images, and can eliminate vessels on CT using 3-dimensionalmulti-scale line filter for segmentation and visualization of curvilinear structures such as vessels, resulting in calculating a rate of pure solid portion volume to whole tumor volume (%Solid) regardless of distribution of solid portions in nodule. Three-dimensional %Solid of adenocarcinomas is feasible for estimating prognosis. Nodule with %Solid>=63% significantly contributed to short overall and disease-free survival.

Research Products

• [Presentation] Three-dimensional (3-D) quantitative analysis of preoperative CT images in pathological stage I pulmonary adenocarcinomas: Correlation with prognostic factors (2012)
  • Organizer: Radiological Society of North America 97th Scientific Assembly and Annual Meeting (RSNA 2011)
  • Place of Presentation: マコーミックプレイス・コンベンションセンター(USA)
• [Presentation] 3次元定量的CT画像解析による予後予測:肺腺癌(病理学的病期分類I期)での検討 (2012)
  • Organizer: 第71回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] Management and Diagnostic Imaging for Minute Pulmonary Nodules with or without Ground-Glass Opacity Radiological Society of North America (2012)
  • Organizer: 98th Scientific Assembly and Annual Meeting (RSNA 2012)
  • Place of Presentation: マコーミックプレイス・コンベンションセンター(USA)
• [Presentation] 3次元定量的CT画像解析による予後予測：肺腺癌（病理学的病期分類I期）での検討 (2012)
  • Author(s): 梁川 雅弘
  • Organizer: 第71回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜（横浜）
• [Presentation] Management and Diagnostic Imaging for Minute Pulmonary Nodules with or without Ground-Glass Opacity (2012)
  • Author(s): 梁川 雅弘
  • Organizer: Radiological Society of North America 98th Scientific Assembly and Annual Meeting (RSNA 2012)
  • Place of Presentation: マコーミックプレイス・コンベンションセンター（USA）
• [Presentation] 3 次元定量的 CT 画像解析による予後予測:肺腺癌(病理学的病期分類I期)での検討 (2011)
  • Organizer: 第52回日本肺癌学会総会
  • Place of Presentation: 大阪
• [Presentation] 3次元定量的CT画像解析による予後予測：肺腺癌（病理学的病期分類I期）での検討 (2011)
  • Author(s): 梁川雅弘、井上匡美、澄川裕充、本多修、小山光博、奥村明之進、富山憲幸
  • Organizer: 第52 回日本肺癌学会総会
  • Place of Presentation: 大阪
• [Presentation] Three-dimensional (3-D) quantitative analysis of preoperative CT images in pathological stage I pulmonary adenocarcinomas: Correlation with prognostic factors. (2011)
  • Author(s): Yanagawa M, Tanaka Y, Morii E, Inoue M, Gyobu T, Kawata Y, Kawai M, Sumikawa H, Koyama M, Honda O, Johkoh T, Okumura M, Tomiyama N
  • Organizer: Radiological Society of North America 97th Scientific Assembly and Annual Meeting (RSNA 2011)
  • Place of Presentation: Chicago, U.S.A.