A basic research of synchrotron microbeam radiation therapy forradiation resistant malignant tumors
| Project/Area Number |
23791424
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 放射光 / 格子状照射 / マイクロビーム / 放射線治療 / Spring－8 / 正常組織耐容線量 |
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| Research Abstract |
Synchrotron microbeam radiation therapy（SMRT) permits the delivery of very high radiation doses to the tumors in a single fraction. In this study, we have challenged to evaluate normal tissue tolerance and mortality by SMRT to the brain of the mice with comparing to broad beam irradiation. Our results including histopathological findings, immunohistologic analysis and functional analysis indicated that the SMRT enables to deliver extremely high doses without loss of normal tissue function.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Long-term outcome and patterns of failure in primary ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiotherapy2012
Author(s)
Hashimoto N, Sasaki R, Nishimura H, Yoshida K, Miyawaki D, Nakayama M, Uehara K, Okamoto Y, Ejima Y, Azumi A, Matsui T, Sugimura K
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 82
Pages: 1509-1514
Related Report
Peer Reviewed
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