Basic dosimetry study for microbeam radiation therapy

• Project/Area Number: 23791425
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kobe University
• Principal Investigator: NAKAYAMA Masao 神戸大学, 医学研究科, 医学研究員 (60582004)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 放射光 / 微小ビーム / 放射線治療 / 線量測定 / Spring-8 / SPring8

Research Abstract

The aim of this study is to evaluate a X-ray microbeam dosimetry at the synchrotron radiation facilities SPring-8. We have focused on the dose measurements in inhomogeneous phantom geometries. The microscope with CCD camera was used to measure the optical-density distribution of GafChromic films irradiated with multi-slit microbeam X-rays. The peak and valley dose rates in inhomogeneous phantom geometries were found to differ according to density variation in phantom. This result suggests that the microbeam dosimetry is required with evaluation of biological effects in microbeam radiation therapy.

Research Products

• [Journal Article] Long-term outcome and patterns of failure in primary ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiotherapy. (2012)
  • Author(s): Hashimoto N
  • Journal Title: Int J Radiat Oncol Biol Phys. Volume: 82(4) Issue: 4 Pages: 1509-1514
  • DOI: 10.1016/j.ijrobp.2011.04.052
  • Peer Reviewed
• [Presentation] Normal tissue tolerance of microplanar beam X-ray : A long-term observation (2013)
  • Author(s): N. Mukumoto, D. Miyawaki, H. Akasaka, M. Nakayama, Y. Miura, K. Umetani, N. Nariyama, K. Shinohara, T. Kondoh, R. Sasaki
  • Organizer: America Society for Radiation Oncology (ASTRO) 55th Annual Meeting
  • Place of Presentation: Atlanta, USA
• [Presentation] Normal tissue tolerance microbeam X-ray irradiation (2013)
  • Author(s): N Mukumoto, R Sasaki, H Akasaka, M Nakayama, K Yoshida, H Nishimura, K Umetani, T Kondo, Y Miura, K Shinohara
  • Organizer: The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: Hiroshima
• [Presentation] Normal tissue tolerance of microplanar beam X-ray : A long-term observation (2013)
  • Author(s): Naritoshi Mukumoto, Daisuke Miyawaki, Hiroaki Akasaka, Masao Nakayama, Yasushi Miura, Keiji Umetani, Nobuteru Nariyama, Kunio Shinohara, Takeshi Kondoh and Ryohei Sasaki
  • Organizer: America Society for Radiation Oncology (ASTRO)
  • Place of Presentation: アトランタ
• [Presentation] マイクロスリットビームX線照射における最適条件の検討 (2012)
  • Author(s): 椋本成俊、佐々木良平、赤坂浩亮、中山雅央、NELLY、西村英輝、吉田賢史、三浦靖史、梅谷啓二、近藤威
  • Organizer: 第25 日本放射線腫瘍学会
  • Place of Presentation: 東京
• [Presentation] マイクロスリットビームX線照射における最適条件の検討 (2012)
  • Author(s): 椋本成俊、佐々木良平、赤坂浩亮、中山雅央、NELLY、西村英輝、吉田賢史、三浦靖史、梅谷啓二、近藤威
  • Organizer: 日本放射線腫瘍学会
  • Place of Presentation: 東京
• [Presentation] Normal tissue tolerance microbeam X-ray irradiation (2012)
  • Author(s): N Mukumoto, R Sasaki, H Akasaka, M Nakayama, K Yoshida, H Nishimura, K Umetani, T Kondo, Y Miura, K Shinohara
  • Organizer: The 6th S.Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
  • Place of Presentation: 広島
• [Presentation] Microplanar Beams Radiation: Is Brain Really A Serial Organs? (2011)
  • Author(s): N. Mukumoto, R. Sasaki, H. Akasaka,M. Nakayama, D. Miyawaki, H. Nishimura, K. Umetani, T. Kondoh, K. Shinohara, K. Sugimura
  • Place of Presentation: Miami, USA
• [Presentation] マイクロスリットビームX線照射に対する正常脳耐容線量の検討 (2011)
  • Author(s): 椋本成俊、佐々木良平、赤坂浩亮、中山雅央、宮脇大輔、西村英輝、吉田賢史、梅谷啓二、近藤威、杉村和朗
  • Organizer: 第24 日本放射線腫瘍学会
  • Place of Presentation: 兵庫
• [Presentation] Microplanar Beams Radiation: Is Brain Really A Serial Organs? (2011)
  • Author(s): N. Mukumoto, R. Sasaki, H. Akasaka, M. Nakayama, D. Miyawaki, H. Nishimura, K. Umetani, T. Kondoh, K. Shinohara, K. Sugimura
  • Organizer: America Society for Radiation Oncology (ASTRO)
  • Place of Presentation: マイアミ
• [Presentation] マイクロスリットビームX線照射に対する正常脳耐容線量の検討 (2011)
  • Author(s): 椋本成俊、佐々木良平、赤坂浩亮、中山雅央、宮脇大輔、西村英輝、吉田賢史、梅谷啓二、近藤威、杉村和朗
  • Organizer: 日本放射線腫瘍学会
  • Place of Presentation: 神戸
• [Book] 放射線医学総論 （第14章放射線物理学を執筆） (2011)
  • Author(s): （監修）楢林 勇、杉村 和朗、（編集）富山 憲幸、中川 恵一
  • Total Pages: 176
  • Publisher: 金芳堂
• [Remarks] Spring-8 利用課題実験報告書
  • URL: https://user.spring8.or.jp/apps/experimexperimen/detail/12180/ja
• [Remarks] Spring-8 利用課題実験報告書
  • URL: https://user.spring8.or.jp/apps/experimexperimen/detail/13631/ja
• [Remarks] SPring8利用課題実験報告書
  • URL: https://user.spring8.or.jp/apps/experimentreport/detail/12180/ja
• [Remarks] SPring8利用課題実験報告書
  • URL: https://user.spring8.or.jp/apps/experimentreport/detail/13631/ja