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Feasibility study of Fiber-Tracted Radiation Therapy for Malignant Glioma

Research Project

Project/Area Number 23791428
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionKobe University

Principal Investigator

UEHARA Kazuyuki  神戸大学, 医学研究科, 医学研究員 (80582006)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords放射線治療学 / 拡散テンソル解析 / 放射線治療 / 悪性グリオーマ
Research Abstract

The relationship with the pattern of failure for glioblastoma and nerve fibers inside the brain has not been considered on the radiotherapy for glioblastoma. We published a paper regarding recurrence pattern of malignant glioma and effectiveness of MIB-1 Labeling index for predicting the pattern of failure in glioblastoma. In addition, we evaluated the efficacy of diffusion tensor imaging into radioation treatment planning. Our results suggested a possibility that Diffusion Tensor imaging can used to reduce the radiation dose to normal brain, and escalated the radiation dose to primary tumor.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (10 results)

All 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (6 results)

  • [Journal Article] Patterns of failure after multimodal treatments for high-grade glioma: effectiveness of MIB-1 labeling index2012

    • Author(s)
      K. Uehara, T. Sasayama, D. Miyawaki, H. Nishimura, K. Yoshida, Y. Okamoto, N. Mukumoto, H. Akasaka, M. Nishihara, O .Fujii, T. Soejima, K. Sugimura, E .Kohmura and R. Sasaki
    • Journal Title

      Radiation oncology

      Volume: 7 Pages: 104-115

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Patterns of failure after multimodal treatments for high-grade glioma:2012

    • Author(s)
      Uehara K
    • Journal Title

      Radiat Oncol

      Volume: 26 Issue: 1 Pages: 104-104

    • DOI

      10.1186/1748-717x-7-104

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term outcome and patterns of failure in primary ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiotherapy.2012

    • Author(s)
      Hashimoto N
    • Journal Title

      Int J Radiat Oncol Biol Phys.

      Volume: 82(4) Issue: 4 Pages: 1509-1514

    • DOI

      10.1016/j.ijrobp.2011.04.052

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multi-institutional analysis of solitary extramedullary plasmacytoma of the head and neck treated with curative radiotherapy.2012

    • Author(s)
      Sasaki R
    • Journal Title

      Int J Radiat Oncol Biol Phys.

      Volume: 82(2) Issue: 2 Pages: 626-634

    • DOI

      10.1016/j.ijrobp.2010.11.037

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Combination Efficacy of MGMT Promoter Methylation Status and MIB-1 Labeling Index for Pattern of Recurrence in Glioblastoma Treated with Multimodal Treatment2012

    • Author(s)
      K. Uehara, T. Sasayama, D. Miyawaki, M. Nishihara, K. Yoshida, H. Nishimura, Y. Okamoto, M. Nakayama, N. Mukumoto, H. Akasaka, K. Sugimura, R. Sasaki
    • Organizer
      98th Scientific Assembly and Annual Meeting of The Radiological Society of North America
    • Place of Presentation
      McComick Place Chicago
    • Year and Date
      2012-11-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Impact of MGMT Promoter Methylation Status and MIB-1 Labeling Index on Recurrence Pattern after Multimodal Treatment in Glioblastoma2012

    • Author(s)
      K. Uehara, T. Sasayama, D. Miyawaki, H. Nishimura, K. Yoshida, Y. Okamoto, M. Nishihara, K. Sugimura, R. Sasaki
    • Organizer
      The 6th S. Takahashi Memorial Symposium & The 6th Japan- US Cancer Therapy International Joint Symposium
    • Place of Presentation
      International Conference Center Hiroshima
    • Year and Date
      2012-07-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Combination Efficacy of MGMT Promoter Methylation Status and MIB-1 Labeling Index for Pattern of Recurrence in Glioblastoma Treated with Multimodal Treatment2012

    • Author(s)
      Kazuyuki Uehara
    • Organizer
      98th Scientific Assembly and Annual Meeting of The Radiological Society of North America
    • Place of Presentation
      McCormick Place, Chicago
    • Related Report
      2012 Annual Research Report
  • [Presentation] Impact of MGMT Promoter Methylation Status and MIB-1 Labeling Index on Recurrence Pattern after Multimodal Treatment in Glioblastoma2012

    • Author(s)
      Kazuyuki Uehara
    • Organizer
      The 6th S. Takahashi Memorial Symposium & The 6th Japan-US Cancer Therapy International Joint Symposium
    • Place of Presentation
      広島国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dosimetric Analysis of Patterns of Failure for High-grade Glioma with Multimodality Treatment: Relationship to MIB-1 Labeling Index2011

    • Author(s)
      K. Uehara, R. Sasaki, D. Miyawaki, H. Nishimura, K. Yoshida, M. Nakayama, T. Soejima, O. Fujii, T. Sasayama, and K.Sugimura
    • Organizer
      53rd Annual Meeting of American Society for Radiation Oncology
    • Place of Presentation
      Miami Beach Convention Center
    • Year and Date
      2011-10-06
    • Related Report
      2012 Final Research Report
  • [Presentation] Dosimetric Analysis of Patterns of Failure for High-grade Glioma with Multimodality Treatment: Relationship to MIB-1 Labeling Index2011

    • Author(s)
      K. Uehara
    • Organizer
      American Society for Radiation Oncology (ASTRO) 53rd Annual Meeting
    • Place of Presentation
      Miami Beach Convention Center
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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