The mechanism of amplification in DNA-damage signaling for enhancement of radiosensitivity
| Project/Area Number |
23791434
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Tohoku University (2012)
Nagasaki University (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | DNA二重鎖切断 / 放射線誘発フォーカス形成 / 老化様増殖停止 / 生細胞イメー ジング / 乳がん / 生細胞ライブイメージング / 53BP1 |
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| Research Abstract |
DNA double-strand breaks trigger activation of signal transduction pathways including induction of cell death. Recently, it is suggested that the amplification of DNA damage signaling could be related to the effective cell death induction. In this study, we revealed that the amplification of DNA-damage signaling was suppressed in tumor cell lines.We also demonstrated cell cycle phase-dependency in the amplification of DNA-damage signaling.
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Report
(3 results)
Research Products
(18 results)
