| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Research Abstract |
We tried to evaluate the myocardial metabolism in patients with mitochondrial cardiomyopathy (MC) using magnetic resonance spectroscopy (MRS), in addition to conventional cardiac magnetic resonance imaging (MRI). Optimal imaging conditions for myocardial MRS were proposed the following; 1) Breath-holding and electrocardiac-gating, 2) Trigger delay at end-systole, 3) Setting of ROI in the septum.
Among 3 MC patients evaulated by cardiac MRI, the all had little pericardial fat and normal left ventricular ejection fraction. Left ventricular hypertrophy and fibrosis were obsered in a patient, respectively. Myocardial MRS showed no increased intramyocardial fat accumulation in 2 patients, and resulted in failure in a patient. These 3 MC patients had a good cardiovascular prognosis during a 2-year follow-up, however a patients with myocardial fibrosis was repeatedly hospitalized because of neurological deterioration.
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