Evaluation of mitochondrial cardiomyopathy using cardiac magnetic resonance imaging
| Project/Area Number |
23791439
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | MRI / 心筋症 / ミトコンドリア / MRS / 心筋代謝 / 乳酸 / 脂肪 |
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| Research Abstract |
We tried to evaluate the myocardial metabolism in patients with mitochondrial cardiomyopathy (MC) using magnetic resonance spectroscopy (MRS), in addition to conventional cardiac magnetic resonance imaging (MRI). Optimal imaging conditions for myocardial MRS were proposed the following; 1) Breath-holding and electrocardiac-gating, 2) Trigger delay at end-systole, 3) Setting of ROI in the septum.
Among 3 MC patients evaulated by cardiac MRI, the all had little pericardial fat and normal left ventricular ejection fraction. Left ventricular hypertrophy and fibrosis were obsered in a patient, respectively. Myocardial MRS showed no increased intramyocardial fat accumulation in 2 patients, and resulted in failure in a patient. These 3 MC patients had a good cardiovascular prognosis during a 2-year follow-up, however a patients with myocardial fibrosis was repeatedly hospitalized because of neurological deterioration.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Refractory high output heart failure in a patient with primary mitochondrial respiratory chain disease2014
Author(s)
Nakagawa H, Okayama S, Kamon D, Nakano T, Onoue K, Kawakami R, Horii M, Sakaguchi Y, Uemura S, Takemura G, Saito Y.
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Journal Title
Intern Med
Volume: 53(4)
Pages: 315-9
NAID
Related Report
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[Journal Article] Refractory high output heart failure in a patient with primary mitochondrial respiratory chain disease.2014
Author(s)
Nakagawa H, Okayama S, Kamon D, Nakano T, Onoue K, Kawakami R, Horii M, Sakaguchi Y, Uemura S, Takemura G, Saito Y.
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Journal Title
Intern Med.
Volume: 53
Pages: 315-319
NAID
Related Report
Peer Reviewed
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[Presentation] ミトコンドリア病4例の検討2012
Author(s)
杉本雅史,岡山悟志,中川仁,中野知哉,對馬英雄,鴨門大輔,岡田定規,上村史朗,藤本眞一,斎藤能彦
Organizer
第114回日本循環器学会近畿地方会
Place of Presentation
大阪
Year and Date
2012-12-15
Related Report
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[Presentation] MRSにより心筋内脂肪蓄積を評価し得た糖尿病合併心尖部肥大型心筋症の1例2012
Author(s)
岡山悟志,菅原裕,上田友哉,松本貴樹,岡田定規,西田卓,添田恒有,染川智,竹田征治,川田啓之,川上利香,上村史朗,斎藤能彦
Organizer
第113回日本循環器学会近畿地方会
Place of Presentation
大阪
Year and Date
2012-06-16
Related Report
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