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Evaluation of the Role of Cisplatin-conjugated-soluble Gelatin Sponge: Feasibility Study in a Swine Model.

Research Project

Project/Area Number 23791440
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Radiation science
Research InstitutionWakayama Medical University

Principal Investigator

IKOMA Akira  和歌山県立医科大学, 医学部, 学内助教 (60458065)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords抗癌剤 / 徐放性 / RM-Gelatin / 動注療法 / IVR / 溶解型ゼラチン / 動脈塞栓術 / シスプラチン / RM-ゼラチン
Research Abstract

PURPOSE: To evaluate the safety and the delivery function of cisplatin-conjugated-soluble gelatin sponge in a swine model.METHODS: Fifteen healthy young swine were assigned into three groups: transarterial cisplatin infusion group, transarterial chemoembolization (TACE) with cisplatin-conjugated 120-min soluble gelatin sponge (TACE-120) group, and TACE with cisplatin-conjugated 360-min soluble gelatin sponge (TACE-360) group. A total volume of 0.8 mL/kg cisplatin in each group and 8 mg/kg soluble gelatin sponge in TACE-120 and TACE-360 groups were injected from the left hepatic artery in small increments for 10 min. Common hepatic angiography and whole-blood sampling via the left hepatic vein were conducted to explore recanalization immediately after the procedure and again at 10, 30, 60, 90, 120, 180, 240, 300, 360, and 420 min later. The area under the plasma concentration curve (AUC) of non-protein-bound platinum was compared among the three groups. Each liver was removed and cut into 10-cm-thick sections for calculating liver-damaged volume ratio. RESULTS: Sequential angiography depicted gradual recanalization of the occluded hepatic artery and total recanalization at 120 and 360 min after embolization in the TACE-120 and TACE-360 groups, respectively. Of the three groups, AUC(0-30), AUC(30-120), and AUC(120-420) were significantly highest in the transarterial cisplatin infusion group (p < 0.001), the TACE-120 group (p < 0.001), and the TACE-360 group (p < 0.001), respectively. The liver-damaged volume ratio in the TACE-360 group was small (8.20 %) but significantly higher than that in the TACE-120 group (2.67 %, p = 0.014). CONCLUSION: Cisplatin-conjugated soluble gelatin sponge functions as a cisplatin carrier and is associated with tolerable liver damage

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2013 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (3 results)

  • [Journal Article] Evaluation of the Role of Cisplatin-conjugated-soluble Gelatin Sponge: Feasibility Study in a Swine Model2013

    • Author(s)
      Ikoma A, Kawai N, Sato M, Minamiguchi H, Nakata K, Nakai M, Sanda H, Sonomura T, Kanayama Y, Sakai Y
    • Journal Title

      Cardiovasc Intervent Radiol

      Volume: 36.4 Pages: 1097-104

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the role of cisplatin conjugated-soluble gelatin sponge: feasibility study in a swine model.2013

    • Author(s)
      Ikoma Akira
    • Journal Title

      Cardiovasc Intervent Radiol

      Volume: 36 Issue: 4 Pages: 1097-1104

    • DOI

      10.1007/s00270-012-0499-5

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Evaluation of soluble gelatin sponge as a role of cisplatin-carrier: basic study in a swine model2012

    • Author(s)
      M.Sato.
    • Organizer
      SIR
    • Place of Presentation
      SanFrancisco
    • Year and Date
      2012-03-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 溶解型ゼラチンスポンジのシスプラチンキャリアーとしての有用性の検討2011

    • Author(s)
      生駒 顕
    • Organizer
      日本 IVR 学会総会
    • Place of Presentation
      青森
    • Year and Date
      2011-05-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 正常豚における溶解型ゼラチンスポンジのシスプラチンキャリアーとしての有用性の検討

    • Author(s)
      Sato M
    • Organizer
      SIR
    • Place of Presentation
      アメリカ
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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