| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
Chronic kidney disease (CKD) is characterized by tubular atrophy and interstitial fibrosis. These pathological changes are caused by decreased renal oxygenation, which initiates and promotes a fibrotic response. Therefore, an evaluation of the degree of fibrosis/hypoxia and renal blood flow in CKD patients is beneficial for the determination of the prognosis of CKD.
For the evaluation of CKD patients in this study, we employed (1) blood oxygen level-dependent magnetic resonance imaging (MRI) for the noninvasive assessment of tissue oxygen bioavailability, (2) diffusion-weighted MRI for the measurement of the apparent diffusion coefficients reflecting the degree of interstitial fibrosis, and (3) arterial spin labeling for the noninvasive measurement of tissue perfusion. We believe that this method will play a significant role in drug development as it can evaluate changes in the physical condition of the kidney prior to changes in serum creatinine and proteinuria.
|
