Initial investigation of predicting radiosensitivity and optimal dose fractionation against glioblastoma

• Project/Area Number: 23791445
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Keio University
• Principal Investigator: FUKADA Junichi 慶應義塾大学, 医学部, 助教 (50338159)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 膠芽腫 / 低分割放射線治療 / 悪性膠芽腫

Research Abstract

Various single dose irradiation was performed to several malignantglioma cell lines to obtain survival curves. Radiation sensitivity was significantly high in LN 229 cell line (wild type) by high dose irradiation exceeding 8Gy. Gene mutation of PTEN and p

Research Products

• [Presentation] 聴神経腫瘍に対する定位放射線照射の治療成績 (2012)
  • Author(s): 深田淳一, 国枝悦夫, 川口修, 関智史, 大平貴之, 井上泰宏, 柴秀行,小池直義, 武居秀行, 茂松直之
  • Organizer: 日本放射線腫瘍学会第25回学術大会
  • Place of Presentation: 東京
• [Presentation] 聴神経腫瘍に対する定位放射線照射の治療成績 (2012)
  • Author(s): 深田淳一
  • Organizer: 日本放射線腫瘍学会第25回学術大会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] Cucinotta Enhanced repair fidelity under non-cycling conditionsin X-ray irradiated fibroblasts accounts for increased potentiallylethal damage repair but not in high-LET irradiated fibroblasts (2011)
  • Author(s): Tetsuya Kawata, C. Liu, N. Shigematsu,J. Fukada, Y. Furusawa, H. Ito, K. George, F.
  • Organizer: 第14回国際放射線研究会議
  • Place of Presentation: ワルシャワ ポーランド
• [Presentation] Enhanced repair fidelity under non-cycling conditions in X-ray irradiated fibroblasts accounts for increased potentially lethal damage repair but not in high-LET irradiated fibroblasts.
  • Author(s): Tetsuya Kawata, C. Liu, N. Shigematsu, J. Fukada, Y. Furusawa, H. Ito, K. George, F.Cucinotta
  • Organizer: 14th International Congress of Radiation Research
  • Place of Presentation: ポーランド、ワルシャワ