A research on the optimal protocol for cryoablation of endocrine organ including adrenal gland and thyroid gland

• Project/Area Number: 23791448
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Keio University
• Principal Investigator: SOTA Oguro 慶應義塾大学, 医学部, 助教 (50383716)
• Research Collaborator: NAKATSUKA Seishi 慶應義塾大学, 医学部, 講師 (50188984) ; INOUE Masanori 慶應義塾大学, 医学部, 助教 (30338157) ; KAWAMURA Masafumi 帝京大学, 医学部, 教授 (70169770)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 凍結療法 / 副腎 / 甲状腺 / 副腎の凍結療法 / 甲状腺の凍結療法

Research Abstract

Cryoablation of the adrenal gland caused a hypertensive crisis during thawing. This hypertensive crisis was conducted by high plasma catecholamines and was observed rapidly. We concluded that the blood pressure should be monitored and controlled using arterial blood pressure and arterial infusion of alpha-blocker.
Cryoablation of the thyroid gland revealed that the area of the ice ball was significantly smaller than that of liver or kidney. The size of the ice ball was different in each experiments. This difference in the size of the ice ball was caused by "heat sink effect" by a regional vessels including common carotid artery or vein.

Research Products

• [Presentation] ブタ甲状腺の凍結療法時におけるホルモンおよびバイタルの変化について (2012)
  • Author(s): 小黒草太、中塚誠之、井上政則、橋本統、栗林幸夫
  • Organizer: 第13回RFA談話会
  • Place of Presentation: 三重大学医学部附属病院
  • Year and Date: 2012-07-14
• [Presentation] Transcatheter Arterial Chemoembolization (TACE) of Liver Metastases From Malignant Pheochromocytoma of the Adrenal Gland (2012)
  • Author(s): S. Oguro, S. Hashimoto, Y. Matsusaka, M. Inoue, S. Nakatsuka, S. Kuribayashi
  • Organizer: APCCVIR
  • Place of Presentation: Kobe Portopia Hotel, Kobe Japan
  • Year and Date: 2012-05-11
• [Presentation] Hemodynamic and hormonal changes during cryoablation of adrenal gland in swine : in vivo experimental study (2011)
  • Author(s): M. Inoue, S. Nakatsuka, H. Yashiro, S. Oguro, N. Ito, Y. Yamauchi, K. Hashimoto, K. Asakura, N. Tsukada, Y. Izumi, M. Kawamura, S. Kuribayashi
  • Organizer: CIRSE
  • Place of Presentation: Munich Germany
• [Presentation] Hemodynamic and hormonal changes during cryoablation of adrenal gland in swine: in vivo experimental study (2011)
  • Author(s): M. Inoue, S. Nakatsuka, H. Yashiro, S. Oguro, N. Ito, Y. Yamauchi, K. Hashimoto, K. Asakura, N. Tsukada, Y. Izumi, M. Kawamura, S. Kuribayashi
  • Organizer: CIRSE 2011
  • Place of Presentation: Munich, Germany
• [Presentation] 甲状腺の凍結療法時におけるホルモンおよびバイタルの変化について
  • Author(s): 小黒 草太、中塚 誠之、井上 政則、橋本 統、栗林 幸夫
  • Organizer: 第 13 回 RFA 談話会プログラム
  • Place of Presentation: 三重大学医学部附属病院