Myocardial imaging of radiolabeled anti HIF-1 antibody in infarct rat

• Project/Area Number: 23791452
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: FUKUSHIMA Kenji 東京女子医科大学, 医学部, 准講師 (50408613)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 心臓核医学 / 心筋梗塞 / 小動物 / 小動物イメージング / 虚血 / 画像診断 / イメージング / 小動物実験 / 虚血性心疾患 / 心筋イメージング / 核医学

Outline of Final Research Achievements

The feasibility of myocardial imaging of radiolabeled anti HIF-1 antibidy was evaluated. In acute infarction model, significant uptake signal from infarct myocardium was observed, but in chronic myocardial infarction model, myocardial imaging was not detectable. Anti HIF-1 imaging was thought to feasible in acute phase, but not in chronic phase. We also performed comparison study for total occlusion and re-perfusion model. There was significant myocardial signal uptake in re-perfusion model, but not in total occlusion model.