Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Outline of Final Research Achievements |
The feasibility of myocardial imaging of radiolabeled anti HIF-1 antibidy was evaluated. In acute infarction model, significant uptake signal from infarct myocardium was observed, but in chronic myocardial infarction model, myocardial imaging was not detectable. Anti HIF-1 imaging was thought to feasible in acute phase, but not in chronic phase. We also performed comparison study for total occlusion and re-perfusion model. There was significant myocardial signal uptake in re-perfusion model, but not in total occlusion model.
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