| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
The parametric X-ray radiation can use at LEBRA, Nihon University. The silicon crystal has been used as a radiation source. However, higher energy PXR is necessary for the future clinical application as medical images or treatments. We hypothesized that the use of diamond crystal as a radiation source could be useful for higher energy. As the results, tunable PXR beam from the diamond crystal was successfully observed and X-ray imaging was carried out using the PXR beam up to 60 keV.
124I-HPPH has been developed for photodynamic therapy. We hypothesize that HPPH with cold iodine (1276I-HPPH, 717), which occurs as an intermediate product in 124I-HPPH synthesis, can act as a new specific and selective radiosensitizer, because iodine is used as a contrast agent in clinical X-ray imaging. In this study, we evaluated the radiosentizing activity of 717 in a human bladder cancer cell line (T24). We revealed that Utilization of 717 has a advantages as a radio sensitizer.
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