Development of new photon activation therapy with use of parametric X-ray
| Project/Area Number |
23791453
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 光線力学療法 / パラメトリックX線照射 / 放射線増感剤 / パラメトリックX線放射 / ポルフィリン / パラメトリック単色X線放射 / 放射線増感 |
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| Research Abstract |
The parametric X-ray radiation can use at LEBRA, Nihon University. The silicon crystal has been used as a radiation source. However, higher energy PXR is necessary for the future clinical application as medical images or treatments. We hypothesized that the use of diamond crystal as a radiation source could be useful for higher energy. As the results, tunable PXR beam from the diamond crystal was successfully observed and X-ray imaging was carried out using the PXR beam up to 60 keV.
124I-HPPH has been developed for photodynamic therapy. We hypothesize that HPPH with cold iodine (1276I-HPPH, 717), which occurs as an intermediate product in 124I-HPPH synthesis, can act as a new specific and selective radiosensitizer, because iodine is used as a contrast agent in clinical X-ray imaging. In this study, we evaluated the radiosentizing activity of 717 in a human bladder cancer cell line (T24). We revealed that Utilization of 717 has a advantages as a radio sensitizer.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] AN IODINE LABELED PORPHYRIN AS A NEW RADIATION SENSITIZER IN HUMAN BLADDER CANCER CELLS IN VITRO AND IN VIVO, COMBINATING PHOTODYNAMIC THERAPY (PDT) AND PHOTON ACTIVATION THERAPY (PAT)2013
Author(s)
Ishibashi N, Fujiwara K, Pandey K R, Kataba M, Oguni A, Igarashi J, Soma M, Shizukuishi T, Maebayashi T, Abe K, Abe O, Takahashi M and Tanaka Y.
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Journal Title
Journal of Nihon University Medical Association
Volume: 72(4)
Pages: 212-219
Related Report
Peer Reviewed
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[Journal Article] AN IODINE LABELED PORPHYRIN AS A NEW RADIATION SENSITIZER IN VIVO, COMBINING PHOTODYNAMIC THERAPY (PDT) WITH PHOTON ACTIVATION THERAPY (PAT)2013
Author(s)
Naoya Ishibashi, Kyoko Fujiwara, Ravindra K. Pandey, Motoaki Kataba, Asako Oguni, Jun Igarashi, Masayoshi Soma, Takashi Shizukuishi, Toshiya Maebayashi, Katumi Abe, Osamu Abe, Motoichiro Takahashi and Yoshiaki Tanaka
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Journal Title
J.NIHON Univ.Med.Ass
Volume: 72
Pages: 212-219
Related Report
Peer Reviewed
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