Development of PET probes to aim early diagnosis and evaluation of treatment for eating disorders

• Project/Area Number: 23791466
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: KAWAMURA Kazunori 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (50401766)
• Research Collaborator: ZHANG Ming-rong 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, プログラムリーダー ; FUJINAGA Masayuki 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 ; YUI Joji 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 技術員 ; YAMASAKI Tomoteru 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 ; XIE Lin 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 博士研究員 ; HATORI Akiko 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 主任研究員 ; KUMATA Katsushi 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 技術員 ; WAKIZAKA Hidekatsu 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 准技術員 ; HASHIMOTO Hiroki 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 薬剤師
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: PET / 放射性薬剤 / 分子イメージング / イミダゾリン受容体 / グレリン受容体 / 摂食 / GHS-R

Research Abstract

In this research, we developed PET probes that have a high selectivity and affinity for imaging imidazoline I2 receptors (I2Rs). I2Rs have a high density in the hypothalamic feeding center. Then we suggest that the PET probe ([18F]FEBU) has a potent PET probes for imaging I2Rs and hypothalamic feeding center. Furthermore, we also developed a high selectivity and affinity PET probes for imaging ghrelin receptors and metabotropic glutamate receptor subtype 5,that relate to eating functions. Therefore, PET study using these PET probes is a promising early diagnosis and evaluation of treatment for eating disorders.

Research Products

• [Journal Article] Binding potential of (E)-[11C]ABP688 to metabotropic glutamate receptor subtype 5 is decreased by the inclusion of its 11C-labelled Z-isomer. (2014)
  • Author(s): Kawamura K, Yamasaki T, Kumata K, Furutsuka K, Takei M, Wakizaka H, Fujinaga M, Kariya K, Yui J, Hatori A, Xie L, Shimoda Y, Hashimoto H, Hayashi K, Zhang MR.
  • Journal Title: Nuclear Medicine and Biology Volume: 41 Issue: 1 Pages: 17-23
  • DOI: 10.1016/j.nucmedbio.2013.09.008
  • Peer Reviewed
• [Journal Article] PET study using [^<11>C]FTIMD with ultra-high specific activity to evaluate I_2-imidazoline receptors binding in rat brains (2012)
  • Author(s): Kawamura K、Kimura Y、Yui J、Wakizaka H、Yamasaki T、Hatori A、Kumata K、Fujinaga M、Yoshida Y、Ogawa M、Nengaki N、Fukumura T、Zhang MR
  • Journal Title: Nucl Med Biol Volume: 39巻 Issue: 2 Pages: 199-206
  • DOI: 10.1016/j.nucmedbio.2011.07.008
  • Peer Reviewed
• [Presentation] 代謝型グルタミン酸受容体サブタイプ5選択的PET用リガンド[^<11>C]ABP688のZ異性体混入による脳PET測定の影響 (2013)
  • Author(s): 河村和紀、山﨑友照、熊田勝志、古塚賢士、武井誠、由井譲二、羽鳥晶子、謝琳、藤永雅之、橋本裕輝、張明栄
  • Organizer: 第53回日本核医学会学術総会
  • Place of Presentation: 福岡
• [Presentation] Efficient production of (E)-^<11>C-ABP688 by the HPLC separation, as a useful PET probe for the imaging of the metabotropic glutamate receptor subtype 5 (2013)
  • Author(s): Kazunori Kawamura、Kenji Furutsuka、Tomoteru Yamasaki、Katushi Kumata、Makoto Takei、Joji Yui、Akiko Hatori、Lin Xie、Hiroki Hashimoto、Ming-Rong Zhang
  • Organizer: Society of Nuclear Medicine and Molecular Imaging 2013 Annual Meeting
  • Place of Presentation: バンクーバー(カナダ)
• [Presentation] Synthesis and evaluation of ^<18>F- and ^<11>C-labeled ghrelin receptor ligand as a PET probe (2013)
  • Author(s): Kawamura Kazunori、Fujinaga Masayuki、Yui Joji、Yamasaki Tomoteru、Hatori Akiko、Xie Lin、Wakizaka Hidekatsu、Kumata Katsushi、Yoshida Yuichiro、Ogawa Masanao、Nengaki Nobuki、Zhang Ming-Rong
  • Organizer: The 20th International Symposium on Radiopharmaceutical Sciences
  • Place of Presentation: 済州島(韓国)
• [Presentation] Efficient production of (E)-11C-ABP688 by the HPLC separation, as a useful PET probe for the imaging of the metabotropic glutamate receptor subtype 5 (2013)
  • Author(s): Kazunori Kawamura, Kenji Furutsuka, Tomoteru Yamasaki, Katushi Kumata, Makoto Takei, Joji Yui, Akiko Hatori, Lin Xie, Hiroki Hashimoto, and Ming-Rong Zhang
  • Organizer: Society of Nuclear Medicine and Molecular Imaging Annual Meeting 2013
  • Place of Presentation: Vancouver, Canada
• [Presentation] 代謝型グルタミン酸受容体サブタイプ5選択的PET用リガンド[11C]ABP688のZ異性体混入による脳PET測定の影響 (2013)
  • Author(s): 河村和紀、山崎友照、熊田勝志、古塚賢士、武井誠、由井譲二、羽鳥晶子、謝琳、藤永雅之、橋本裕輝、張明栄
  • Organizer: 第53回日本核医学会学術総会
  • Place of Presentation: 福岡
• [Presentation] Synthesis and evaluation of 18F- and 11C-labeled ghrelin receptor ligand as a PET probe (2013)
  • Author(s): 河村和紀、藤永雅之、由井譲二、山崎友照、羽鳥晶子、謝琳、脇坂秀克、熊田勝志、吉田勇一郎、小川政直、念垣信樹、張明栄
  • Organizer: The 20th International Symposium on Radiopharmaceutical Sciences
  • Place of Presentation: Jeju, Korea
• [Presentation] Imaging of [^<11>C]FTIMD binding to I_2-imidazoline receptors in the rat and monkey brain (2011)
  • Author(s): Kazunori Kawamura、Jun Maeda、Joji Yui、Akiko Hatori、Tomoteru Yamasaki、Hidekatsu Wakisaka、Takashi Okauchi、Yuichi Kimura、Toshimitsu Fukumura、Ming-Rong Zhang
  • Organizer: Society of Nuclear Medicine 2011 Annual Meeting
  • Place of Presentation: サンアントニオ(アメリカ)
• [Presentation] Imaging of [11C]FTIMD binding to I2-imidazoline receptors in the rat and monkey brain. (2011)
  • Author(s): Kazunori Kawamura, Jun Maeda, Joji Yui, Akiko Hatori, Tomoteru Yamasaki, Hidekatsu Wakisaka, Takashi Okauchi, Yuichi Kimura, Toshimitsu Fukumura, Ming-Rong Zhang
  • Organizer: Society of Nuclear Medicine 2011 Annual Meeting
  • Place of Presentation: サンアントニオ（USA）