| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Multidrug resistance-associated protein 1 (MRP1) is ubiquitously expressed in the body and transports various xenobiotics out of cells. The alteration of MRP1 expression is associated with certain diseases. The aim of this study was to examine the feasibility of imaging MRP1 function in peripheral tissues using a 11C-labeled probe with a purine skeleton. In the lung tissue, the probe is transported by MRP1 but not P-glycoprotein or breast cancer resistance protein, suggesting that the probe allows for noninvasive measurement of pulmonary MRP1 function.
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