Imaging of the function of efflux transporters in peripheral tissues
Project/Area Number |
23791468
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Radiation science
|
Research Institution | National Institute of Radiological Sciences |
Principal Investigator |
OKAMURA Toshimitsu 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (80443068)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 放射性医薬品 / 分子イメージング / PET薬剤 / PET薬剤 / トランスポータ |
Research Abstract |
Multidrug resistance-associated protein 1 (MRP1) is ubiquitously expressed in the body and transports various xenobiotics out of cells. The alteration of MRP1 expression is associated with certain diseases. The aim of this study was to examine the feasibility of imaging MRP1 function in peripheral tissues using a 11C-labeled probe with a purine skeleton. In the lung tissue, the probe is transported by MRP1 but not P-glycoprotein or breast cancer resistance protein, suggesting that the probe allows for noninvasive measurement of pulmonary MRP1 function.
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Report
(3 results)
Research Products
(8 results)