Optimization of radiation therapy for liver cancer using SPIO-MRImonitoring the degradation of SPIO by Kupffer cells

• Project/Area Number: 23791476
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: The University of Tokyo (2012); National Cancer Center Japan (2011)
• Principal Investigator: FURUTA Toshihiro 東京大学, 医科学研究所, 助教 (20597885)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: SPIO / 肝臓 / 放射線照射 / 核磁気共鳴画像（MRI）

Research Abstract

We explored a new MR imaging technique for visualizing irradiated liver parenchyma several days after the start of irradiation. We gave SPIO to rats prior to hepatic irradiation and performed serial MRI examinations to assess the changes in hepatic signal intensity. Hepatic signal intensity recovered to the normal range later in irradiated areas than non-irradiated areas, suggesting that degradation of SPIO by Kupffer cells was delayed in the irradiated areas. The increased number of iron deposits in Kupffer cells in irradiated areas supported the delayed degradation of SPIO.

Research Products

• [Journal Article] Delay hepatic signal recovery on ferucarbotran-enhanced magnetic resonance images:an experimental study in rat livers with gadolinium chloride-induced Kupffer cell damage. (2012)
  • Author(s): Furuta T, Yamaguchi M, Nakagami R, et al.
  • Journal Title: Magnetic Resonance Materials in Physics, Biology and Medicine Volume: 印刷中 Issue: 3 Pages: 313-324
  • DOI: 10.1007/s10334-012-0354-3
  • Peer Reviewed
• [Presentation] SPIO-MRIによる肝癌の放射線治療マージン描出に関する実験的検討 (2012)
  • Author(s): 古田寿宏、山口雅之、中神龍太朗、赤羽正章、南学、大友邦、藤井博史
  • Organizer: 第40回日本磁気共鳴医学会大会
  • Place of Presentation: 京都
• [Presentation] SPIO-MRIによる肝癌の放射線治療マージン描出に関する実験的検討 (2012)
  • Author(s): 古田寿宏
  • Organizer: 第40回日本磁気共鳴医学会大会
  • Place of Presentation: 国立京都国際会館
• [Presentation] クッパー細胞の鉄分解機能に着目したSPIO-MRIによる新しい肝障害評価法:ラット肝での実験的検討 (2011)
  • Author(s): 古田寿宏、山口雅之、中神龍太朗、赤羽正章、南学、大友邦、藤井博史
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 小倉
  • Year and Date: 2011-09-29
• [Presentation] A new technique for the detection of liver damage by evaluation of impaired exocytotic activity of Kupffer cells; an experimental study of gadolinium chloride-induced liver injury in rats (2011)
  • Author(s): Toshihiro Furuta, Masayuki Yamaguchi, Ryutaro Nakagami, Masaaki Akahane, Manabu Minami, Kuni Ohtomo, and Hirofumi Fujii.
  • Organizer: ISMRM 19th annual meeting & exhibition
  • Place of Presentation: モントリオール、カナダ
  • Year and Date: 2011-05-10
• [Presentation] A new technique for the detection of liver damage by evaluation of impaired exocytotic activity of Kupffer cells; an experimental study of gadolinium chloride-induced liver injury in rats (2011)
  • Author(s): Toshihiro Furuta, Masayuki Yamaguchi, Ryutaro Nakagami, Masaaki Akahane, Manabu Minami, Kuni Ohtomo, and Hirofumi Fujii
  • Organizer: ISMRM 19th annual meeting & exhibition
  • Place of Presentation: モントリオール 国名：カナダ
• [Presentation] クッパー細胞の鉄分解機能に着目したSPIO-MRIによる新しい肝障害評価法：ラット肝での実験的検討 (2011)
  • Author(s): 古田寿宏、山口雅之、中神龍太朗、赤羽正章、南学、大友邦、藤井博史
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 小倉