| Project/Area Number |
23791477
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Shizuoka Cancer Center Research Institute |
|---|
Principal Investigator |
KASE Yuki 静岡県立静岡がんセンター(研究所), 陽子線治療研究部, 研究員 (70455385)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
|
|---|
| Keywords | 粒子線治療 / 深部線量分布 / 生物学的効果比 / 陽子線治療 / 生物学的効果 / Microdosimetry / 線量分布 / 拡大ブラッグピーク / RBE |
|---|
| Research Abstract |
The purpose of this study was to establish a relative biological effectiveness (RBE) calculation method for designing therapeutic proton beams. The tissue-equivalent proportional counter was used to measure the microdosimetric lineal energy spectra for proton beams. The RBE-weighted absorbed dose distribution for a therapeutic proton beam was derived by a mixing calculation from the measured spectra for a mono-energetic beam, and it agreed well with that directly derived from the microdosimetric spectra of the therapeutic beam. The measurement for the mono-energetic proton beam was also useful for designing RBE-weighted absorbed dose distributions for range-modulated proton beams.
|
