Development of a biological dose calculation model for proton therapy

• Project/Area Number: 23791477
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Shizuoka Cancer Center Research Institute
• Principal Investigator: KASE Yuki 静岡県立静岡がんセンター(研究所), 陽子線治療研究部, 研究員 (70455385)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
• Keywords: 粒子線治療 / 深部線量分布 / 生物学的効果比 / 陽子線治療 / 生物学的効果 / Microdosimetry / 線量分布 / 拡大ブラッグピーク / RBE

Research Abstract

The purpose of this study was to establish a relative biological effectiveness (RBE) calculation method for designing therapeutic proton beams. The tissue-equivalent proportional counter was used to measure the microdosimetric lineal energy spectra for proton beams. The RBE-weighted absorbed dose distribution for a therapeutic proton beam was derived by a mixing calculation from the measured spectra for a mono-energetic beam, and it agreed well with that directly derived from the microdosimetric spectra of the therapeutic beam. The measurement for the mono-energetic proton beam was also useful for designing RBE-weighted absorbed dose distributions for range-modulated proton beams.

Research Products

• [Journal Article] Microdosimetric calculation of relative biological effectiveness for design of therapeutic proton beams (2013)
  • Author(s): Yuki Kase, Wataru Yamashita, Naruhiro Matsufuji, Kenta Takada, Takeji Sakae, Yoshiya Furusawa, Haruo Yamashita and Shigeyuki Murayama
  • Journal Title: Radiat. Res. Volume: Vo.54 Issue: 3 Pages: 485-493
  • DOI: 10.1093/jrr/rrs110
  • Peer Reviewed
• [Journal Article] Lineal energy-based evaluation of oxidative DNA damage induced by proton beams and X-rays (2013)
  • Author(s): Zhengshan Hong, Yuki Kase, Takashi Moritake, Ariungerel Gerelchuluun, Lue Sun, Kenshi Suzuki, Toshiyuki Terunuma, Kiyoshi Yasuoka, Hiroaki Kumada, Kazunori Anzai, Hideyuki Sakurai, Takeji Sakae and Koji Tsuboi
  • Journal Title: Int. J. Radiat. Biol. Volume: Vol.89 Issue: 1 Pages: 36-43
  • DOI: 10.3109/09553002.2012.715791
  • Peer Reviewed
• [Presentation] 陽子線治療における生物学的効果計算モデルを用いた線量分布計算法の開発 (2012)
  • Author(s): 加瀬優紀ら
  • Organizer: 第103回日本医学物理学会
  • Place of Presentation: 横浜
  • Year and Date: 2012-04-15
• [Presentation] 陽子線治療における生物学的効果計算モデルを用いた線量分布計算法の開発 (2012)
  • Author(s): 加瀬 優紀
  • Organizer: 第103回日本医学物理学会大会
  • Place of Presentation: 横浜
• [Presentation] Performance evaluation of multi-layer ionization chamber for quality assurance of proton therapeutic beam (2011)
  • Author(s): Yuki Kase et al
  • Organizer: The 4th Japan-Korea Joint Meeting on Medical Physics
  • Place of Presentation: Fukuoka
  • Year and Date: 2011-09-30
• [Presentation] Performance evaluation of multi-layer ionization chamber for quality assurance of proton therapeutic beam (2011)
  • Author(s): 加瀬 優紀
  • Organizer: The 4th Japan-Korea Joint Meeting on Medical Physics
  • Place of Presentation: 福岡