| Project/Area Number |
23791478
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Research Institute, Shiga Medical Center |
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Principal Investigator |
KAGAWA SHINYA 滋賀県立成人病センター(研究所), その他部局等, 主任研究員 (10393191)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | アミノ酸 / アミノ酸輸送システムL / [11C]MET / アミノ酸輸送システムA / [11C]MeAIB / PET / [18F]NMeFAMP / C-11 MET / C-11 MeAIB / F-18 NMeFAMP |
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| Research Abstract |
We have developed [N-methyl-11C]alpha-methylaminoisobutyric acid ([11C]MeAIB) PET imaging as a tumor seeking molecular imaging based on system A amino acid transport. The aim of this study was to develop a new artificial amino acid radiopharmaceutical labeled with fluorine-18, which has longer half-life (109 min) than carbon-11 (20 min) and would be widely available in clinical use. To develop novel fluorine-18 labeled tracers, we focused on alpha-Methyl-DL-serine as a starting material. And then we developed a precursor, (R)-3,4-Dimethyl-1,2,3-oxathiazolidine-4-carboxylic acid tert-butyl ester 2,2-dioxide. Labeling of (R)-3-[18F]Fluoro-2-methyl-2-N-(methylamino)propanoic acid ([18F]NMeFAMP) which are fluorinated analogues of MeAIB was carried out conveniently and efficiently in a short period of time (within 90 min). After the purification, [18F]NMeFAMP was obtained with a radiochemical purity greater than 99.9%.
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