Development of a Subcutaneous Site Islet Transplantation Method Using Cell Sheet.
| Project/Area Number |
23791479
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
INAGAKI Akiko 東北大学, 未来科学技術共同研究センター, 助教 (20360224)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 膵島 / 糖尿病 / 移植 / 膵島移植 / 細胞移植 / 皮下移植 / 血管新生 / 移植・再生医療 / 重症糖尿病 |
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| Research Abstract |
We aimed to establish a method to transplant islets of islets to subcutaneous sites with pre-constructed vascular beds by using cell sheets. We found fat-derived stem cells are more appropriate for vascular bed construction prior to subcutaneoustransplantation than basic fibroblast growth factors (bFGF) entailing bloody effusions. In addition, we succeeded in preparing islet cell sheets consisting of islet cell sheets and fibroblasts and in an in vitro sugar tolerance test we confirmed insulin secretion accompanying increase in glucose concentration . However, we could not produce islet cell sheets containing an enough amount of islets to curediabetic animals.
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Report
(3 results)
Research Products
(20 results)
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[Presentation] SatomiDevelopment of a highly efficient collagenase for isolating pancreatic islets2011
Author(s)
Masafumi Goto , Youhei Yamagata, Kimiko Watanabe, Kazutaka Murayama,Takehiro Imura, Akiko Inagaki, Hideyuki Yamaya, Satoshi Sekiguchi, Keisei Fujimori, Yoshimochi Kurokawa, Susumu
Organizer
13th world Congress of IPITA
Place of Presentation
Praha, Czech Republic
Related Report
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