Development of new colorectal cancer treatment using of fatty acid synthase inhibitors

• Project/Area Number: 23791480
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: Teikyo University
• Principal Investigator: MURATA Soichiro 帝京大学, 医学部, 講師 (40436275)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 大腸癌 / 肝転移 / 脂肪酸合成酵素 / オキサリプラチン / セルレニン / エピガロカテキン

Research Abstract

Fatty acid synthase is highly expressed in many kinds of human cancers. Cerulenin, a natural inhibitor of fatty acid synthase, induced apoptosis in human colon cancer cell lines. In xenotransplanted SCID mice, the cerulenin+oxaliplatin group significantly inhibited tumor progression. By using EGCG, liver metastasis of human colon cancer was extremely reduced in SCID mice. Based on these studies, inhibiting fatty acid synthase would be an effective strategy to treat unresectable colorectal cancer.

Research Products

• [Journal Article] Human platelets promote liver regeneration with Kupffer cells in SCID mice (2013)
  • Author(s): Takahashi K, Kozuma Y, Suzuki H, Tamura T, Maruyama T, Fukunaga K, Murata S, Ohkohchi N
  • Journal Title: J Surg Res Volume: 180(1) Pages: 62-72
  • Peer Reviewed
• [Journal Article] Platelet transfusion improves liver function in patients with chronic liver disease and cirrhosis (2013)
  • Author(s): Maruyama T, Murata S, Takahashi K, Tamura T, Nozaki R, Ikeda N, Fukunaga K, Oda T, Sasaki R, Ohkohchi N
  • Journal Title: Tohoku J Exp Med Volume: 229(3) Pages: 213-20
  • NAID: 10031161721
  • Peer Reviewed
• [Journal Article] Effects of throm bopoietin on growth of hepatocellul ar carcinoma : Is thrombopoietin the rapy for liver disease safe or not? (2013)
  • Author(s): Nozaki R, Murata S, Nowatari T, Mar uyama T, Ikeda N, Kawasaki T, Fukun aga K, Ohkohchi N
  • Journal Title: Hepatol Res Volume: 43(6) Issue: 6 Pages: 610-20
  • DOI: 10.1111/hepr.12006
  • Peer Reviewed
• [Journal Article] Protective effect of heme oxygenase-1 on hepatic isch emia-reperfusion injury through inh ibition of platelet adhesion to the sinusoids (2013)
  • Author(s): Tamura T, Kondo T, Ogawa K, Fukunag a K, Ohkohchi N
  • Journal Title: J Surg Res Volume: 180(1) Issue: 1 Pages: 62-72
  • DOI: 10.1016/j.jss.2012.11.030
  • Peer Reviewed
• [Journal Article] Platelet transfusion improves liver function in patients with chronic liver disease and cirrhosis. (2013)
  • Author(s): Maruyama T, Murata S, Takahashi K, Tamura T, Nozaki R, Ikeda N, Fukunaga K, Oda T, Sasaki R, Ohkohchi N.
  • Journal Title: Tohoku Journal of Experimental Medicine Volume: 229 Pages: 213-220
  • NAID: 10031161721
• [Journal Article] Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells. (2013)
  • Author(s): Shiragami R, Murata S, Kosugi C, Tezuka T, Yamazaki M, Hirano A, Yoshimura Y, Suzuki M, Shuto K, Koda K.
  • Journal Title: International Journal of Oncology Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Interaction between Kupffer cells and platelets in the early period of hepatic ischemia-reperfusion injury--an in vivo study (2012)
  • Author(s): Tamura T, Kondo T, Pak S, Nakano Y, Murata S, Fukunaga K, Ohkohchi N
  • Journal Title: J Surg Res Volume: 178(1) Pages: 443-451
  • NAID: 120007137160
  • Peer Reviewed
• [Journal Article] Elovl6 promotes nonalcoholic steatohepatitis (2012)
  • Author(s): Matsuzaka T, Atsumi A, Matsumori R, Nie T, Shinozaki H, Suzuki-Kemuriyama N, Kuba M, Nakagawa Y, Ishii K, Shimada M, Kobayashi K, Yatoh S, Takahashi A, Takekoshi K, Sone H, Yahagi N, Suzuki H, Murata S, Nakamuta M, Yamada N, Shimano H
  • Journal Title: Hepatology Volume: 56(6) Pages: 2199-2208
  • Peer Reviewed
• [Journal Article] Effects of thrombopoietin on growth of hepatocellular carcinoma: Is thrombopoietin therapy for liver disease safe or not? (2012)
  • Author(s): Nozaki R, Murata S, Nowatari T, Maruyama T, Ikeda N, Kawasaki T, Fukunaga K, Ohkohchi N
  • Journal Title: Hepatol Res Volume: (in press)
  • NAID: 10031194563
  • Peer Reviewed
• [Journal Article] Novel therapy for liver regeneration by increasing the number of platelets (2012)
  • Author(s): Takahashi K, Murata S, Ohkohchi N
  • Journal Title: Surg Today Volume: (in press)
  • NAID: 10031201379
• [Journal Article] Platelet derived adenosine 5'-triphosphate suppresses activation of human hepatic stellate cell: In vitro study (2012)
  • Author(s): Ikeda N, Murata S, Maruyama T, Tamura T, Nozaki R, Kawasaki T, Fukunaga K, Oda T, Sasaki R, Homma M, Ohkohchi N
  • Journal Title: Hepatol Res Volume: 42(1) Pages: 91-102
  • NAID: 10031144216
  • Peer Reviewed
• [Journal Article] Differential expression profiles of sense and antisense transcripts between HCV-associated hepatocellular carcinoma and corresponding non-cancerous liver tissue (2012)
  • Author(s): Nagai K, Kohno K, Chiba M, Pak S, Murata S, Fukunaga K, Kobayashi A, Yasue H, Ohkohchi N
  • Journal Title: Int J Oncol Volume: 40(6) Pages: 1813-1820
  • Peer Reviewed
• [Journal Article] Interaction between Kupffer cells and platelets in the early period of hepatic ischemia-reperfusion injury--an in vivo study (2012)
  • Author(s): Tamura T, Kondo T, Pak S, NakanoY, Murata S, Fukunaga K, Ohkohchi N
  • Journal Title: J Surg Res Volume: 178(1) Issue: 1 Pages: 443-51
  • DOI: 10.1016/j.jss.2011.12.010
  • NAID: 120007137160
  • Peer Reviewed
• [Journal Article] Elovl6 promotes nonalcoholic steatohepatitis (2012)
  • Author(s): Takashi Matsuzaka, et al
  • Journal Title: Hepatology Volume: 56 Issue: 6 Pages: 2199-2208
  • DOI: 10.1002/hep.25932
  • Peer Reviewed
• [Journal Article] Novel therapy for liver regeneration by increasing the number of platelets. (2012)
  • Author(s): Takahashi K, Murata S, Ohkohchi N.
  • Journal Title: Surgery Today Volume: 印刷中
  • NAID: 10031201379
• [Journal Article] Platelet-derived adenosine 5'-triphosphate suppresses activation of human hepatic stellate cell: In (2012)
  • Author(s): Ikeda N
  • Journal Title: Hepatology Research Volume: 42 Issue: 1 Pages: 91-102
  • DOI: 10.1111/j.1872-034x.2011.00893.x
  • Peer Reviewed
• [Journal Article] Differential expression profiles of sense and antisense transcripts between HCV-associated hepatocellular carcinoma and corresponding non-cancerous liver tissue. (2012)
  • Author(s): Nagai K
  • Journal Title: International Journal of Oncology Volume: 40 Pages: 1813-1820
  • DOI: 10.3892/ijo.2012.1382
  • Peer Reviewed
• [Journal Article] Impact of three-dimensional analysis of multidetector row computed tomography cholangioportography in operative planning for hilar cholangiocarcinoma (2011)
  • Author(s): Sasaki R, Kondo T, Oda T, Murata S, Wakabayashi G, Ohkohchi N
  • Journal Title: Am J Surg Volume: 202(4) Pages: 441-448
  • Peer Reviewed
• [Journal Article] Elevation and haracteristics of Rab30 and S100a8/S100a9 expression in an early phase of liver regeneration in the mouse (2011)
  • Author(s): Chiba M, Murata S, Myronovych A, Kohno K, Hiraiwa N, Nishibori M, Yasue H, Ohkohchi N
  • Journal Title: Int J Mol Med Volume: 27(4) Pages: 567-574
  • Peer Reviewed
• [Journal Article] Elevation and characteristics of Rab30 and S100a8/S100a9 expression in an early phase of liver regeneration in the mouse (2011)
  • Author(s): Chiba M, Murata S, Myronovych A, Kohno K, Hiraiwa N, Nishibori M, Yasue H, Ohkohchi N
  • Journal Title: Int J Mol Med Volume: 27 Issue: 4 Pages: 567-74
  • DOI: 10.3892/ijmm.2011.614
  • Peer Reviewed
• [Journal Article] Impact of three-dimensional analysis of multidetector row computed tomography cholangioportography in operative planning for hilar cholangiocarcinoma. (2011)
  • Author(s): Sasaki R, Kondo T, Oda T, Murata S, Wakabayashi G, Ohkohchi N.
  • Journal Title: American Journal of Surgery Volume: 202 Pages: 441-448
  • Peer Reviewed
• [Journal Article] Enhanced antitumor activity of cerulenin combined with oxaliplatin in human colon cancer cells
  • Author(s): Shiragami R, Murata S, Kosugi C, Tezuka T, Yamazaki M, Hirano A, Yoshimura Y, Suzuki M, Shuto K, Koda K
  • Journal Title: International Journal of Oncology Volume: (in press)
  • Peer Reviewed
• [Presentation] ヒト大腸癌細胞 HCT116 に対する脂肪酸合成酵素阻害剤と FOLFOX の併用効果の検討 (2013)
  • Author(s): 白神 梨沙、村田 聡一郎、小杉 千弘、平野 敦史、吉村 雪野、山崎 将人、鈴木 正人、首藤 潔彦、幸田 圭史
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2013-04-11
• [Presentation] 大腸癌細胞に対する脂肪酸合成酵素阻害剤とオキサリプラチンの相乗効果の検討 (2012)
  • Author(s): 村田 聡一郎、小杉 千弘、手塚 徹、山崎 将人、平野 敦史、幸田 圭史
  • Organizer: 第67回日本大 腸肛門病学 会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-11-17
• [Presentation] 脂肪酸合成酵素阻害剤セルレニンはオキサリプラチンの効果を増強しヒト大腸癌細胞を抑制する (2012)
  • Author(s): 村田 聡一郎、幸田 圭史、小杉 千弘、手塚 徹、山崎 将人、今井 健一郎、平野 敦史、安田 秀喜
  • Organizer: 第20回日本消化器関連学会週間
  • Place of Presentation: 神戸
  • Year and Date: 2012-10-13
• [Presentation] Epigallocatechin-3-Gallate (EGCG) はヒト大腸癌肝転移を抑制する (2012)
  • Author(s): 丸山 岳人、村田 聡一郎、小川 光一、野渡 剛之、田村 孝史、野崎 礼史、大河内 信弘
  • Organizer: 第48回日本肝癌研究会
  • Place of Presentation: 金沢
  • Year and Date: 2012-07-21
• [Presentation] Epigallocatechin-3-Gallate(EGCG) はヒト大腸癌肝転移を抑制する (2012)
  • Author(s): 丸山 岳人、村田 聡一郎、野渡 剛之、高橋 一広、野崎 礼史、池田 直哉、大河内信弘
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2012-06-07
• [Presentation] ヒト大腸癌肝転移モデルを用いたEpigallocatechin-3-Gallate の抗腫瘍効果の検討 (2011)
  • Author(s): 丸山 岳人、村田 聡一郎、田村 孝史、高橋 一広、野崎 礼史、永井 健太郎、池田 直哉、高野 恵輔、大河内 信弘
  • Organizer: 第19回日本消化器関連学会週間
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-23
• [Presentation] Epigallocatechin-3-Gallate(EGCG)はヒト大腸癌肝転移を抑制する．
  • Author(s): 丸山 岳人, 村田 聡一郎, 野渡 剛之, 高橋 一広, 野崎 礼史, 池田 直哉, 大河内 信弘．
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: 金沢
• [Presentation] Epigallocatechin-3-Gallate (EGCG)はヒト大腸癌肝転移を抑制する．
  • Author(s): 丸山 岳人、村田 聡一郎、小川 光一、野渡 剛之、田村 孝史、野崎 礼史、大河内 信弘
  • Organizer: 第48回日本肝癌研究会
  • Place of Presentation: 金沢
• [Presentation] 脂肪酸合成酵素阻害剤セルレニンはオキサリプラチンの効果を増強しヒト大腸癌細胞を抑制する．
  • Author(s): 村田 聡一郎、幸田 圭史、小杉 千弘、手塚 徹、山崎 将人、今井 健一郎、平野 敦史、安田 秀喜．
  • Organizer: 第20回日本消化器関連学会週間
  • Place of Presentation: 神戸
• [Presentation] 大腸癌細胞に対する脂肪酸合成酵素阻害剤とオキサリプラチンの相乗効果の検討．
  • Author(s): 村田 聡一郎、小杉 千弘、手塚 徹、山崎 将人、平野 敦史、幸田 圭史．
  • Organizer: 第67回日本大腸肛門病学会学術集会
  • Place of Presentation: 福岡
• [Presentation] ヒト大腸癌細胞HCT116に対する脂肪酸合成酵素阻害剤とFOLFOXの併用効果の検討．
  • Author(s): 白神 梨沙、村田 聡一郎、小杉 千弘、平野 敦史、吉村 雪野、山崎 将人、鈴木 正人、首藤 潔彦、幸田 圭史
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡
• [Book] Horizons in cancer research vol 49, Editor Hiroto S (2012)
  • Author(s): Maruyama T, Murata S, Ohkohchi N
  • Publisher: Treatment for liver metastases from colorectal cancer with inhibitor of fatty acid synthase
• [Book] Horizons in cancer research vol 49, Editor Hiroto S. Watanabe (2012)
  • Author(s): Maruyama T, Murata S, Ohkohchi N.
  • Publisher: Nova Science Publishers Inc.