Research Project
Grant-in-Aid for Young Scientists (B)
Fatty acid synthase is highly expressed in many kinds of human cancers. Cerulenin, a natural inhibitor of fatty acid synthase, induced apoptosis in human colon cancer cell lines. In xenotransplanted SCID mice, the cerulenin+oxaliplatin group significantly inhibited tumor progression. By using EGCG, liver metastasis of human colon cancer was extremely reduced in SCID mice. Based on these studies, inhibiting fatty acid synthase would be an effective strategy to treat unresectable colorectal cancer.
All 2013 2012 2011 Other
All Journal Article (22 results) (of which Peer Reviewed: 19 results) Presentation (11 results) Book (2 results)
J Surg Res
Volume: 180(1) Pages: 62-72
Tohoku J Exp Med
Volume: 229(3) Pages: 213-20
10031161721
Hepatol Res
Volume: 43(6) Issue: 6 Pages: 610-20
10.1111/hepr.12006
Volume: 180(1) Issue: 1 Pages: 62-72
10.1016/j.jss.2012.11.030
Tohoku Journal of Experimental Medicine
Volume: 229 Pages: 213-220
International Journal of Oncology
Volume: 印刷中
Volume: 178(1) Pages: 443-451
120007137160
Hepatology
Volume: 56(6) Pages: 2199-2208
Volume: (in press)
10031194563
Surg Today
10031201379
Volume: 42(1) Pages: 91-102
10031144216
Int J Oncol
Volume: 40(6) Pages: 1813-1820
Volume: 178(1) Issue: 1 Pages: 443-51
10.1016/j.jss.2011.12.010
Volume: 56 Issue: 6 Pages: 2199-2208
10.1002/hep.25932
Surgery Today
Hepatology Research
Volume: 42 Issue: 1 Pages: 91-102
10.1111/j.1872-034x.2011.00893.x
Volume: 40 Pages: 1813-1820
10.3892/ijo.2012.1382
Am J Surg
Volume: 202(4) Pages: 441-448
Int J Mol Med
Volume: 27(4) Pages: 567-574
Volume: 27 Issue: 4 Pages: 567-74
10.3892/ijmm.2011.614
American Journal of Surgery
Volume: 202 Pages: 441-448