The elucidation of chronic inflammation by IL-23/Th17 and the application to cancer immunotherapy

• Project/Area Number: 23791482
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: The University of Tokyo
• Principal Investigator: MATSUSHITA Marimo (SATO Marimo) 東京大学, 医科学研究所, 助教 (50401253)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 実験外科学 / IL-23 / Th17 / IL-17 / 癌免疫療法 / 慢性炎症 / 抗腫瘍効果

Research Abstract

Th1 cells and Th17 cells were significantly enhanced by systemic administration of IL-23. However, it is still unknown about the effects of Th17 cells in antitumor immunity. Th17 cells promote an IL-17 production through IL-23 which a macrophage and dendritic cells produce by antigen stimulation in chronic inflammation. In this project, I have found the mechanisms of the antitumor effects of Th17 cells by systemicadministration of IL-23 using wild-type and IL-17 knockout mouse.

Research Products

• [Journal Article] Early activation and interferon-γ production of tumor-infiltrating mature CD27(high) natural killer cells (2011)
  • Author(s): Yoshihiro Hayakawa, Marimo Sato-Matsushita, Kazuyoshi Takeda, Yoichiro Iwakura, Hideaki Tahara, Tatsuro Irimura
  • Journal Title: Cancer Science Volume: 102 Pages: 1967-1971
  • Peer Reviewed
• [Presentation] IL-17-producing NK1.1- CD27- T cells promote tumor malignant progression by inducing inflammatory microenvironment (2012)
  • Author(s): Yoshitaka Kimura, Marimo Sato-Matsushita, Hideaki Tahara, Tatsuro Irimura, Yoshihiro Hayakawa
  • Organizer: 20th International Symposium on Molecular Cell Biology of Macrophages 2012
  • Place of Presentation: Sanjo Conference Hall, The University of Tokyo, Tokyo
• [Presentation] IL-17-producing NK1.1-CD27- T cells promote tumor malignant progression by inducing inflammatorymicroenvironment (2012)
  • Author(s): Yoshihiro Hayakawa, Yoshitaka Kimura, Naoki Tsunekawa, Marimo Sato-Matsushita, Hideaki Tahara, Ikuo Saiki, Tatsuro Irimura
  • Organizer: 第16回日本がん免疫学会総会
  • Place of Presentation: 北海道大学学術交流会館、札幌
• [Presentation] IL-17-producing NK1.1- CD27- T cells promote tumor malignant progression by inducing inflammatory microenvironment (2012)
  • Author(s): 早川芳弘,佐藤(松下)まりも,田原秀晃,済木育夫,入村達郎
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌, 札幌
• [Presentation] IL-17-producing NK1.1- CD27- T cells promote tumor malignant progression by inducing inflammatorymicroenvironment (2012)
  • Author(s): Yoshitaka Kimura, Marimo Sato-Matsushita, Hideaki Tahara, Tatsuro Irimura, Yoshihiro Hayakawa
  • Organizer: 第41回日本免疫学会総会・学術集会
  • Place of Presentation: 神戸国際会議場,神戸
• [Presentation] IL-17-producing NK1.1+ CD27+ T cells promote tumor malignant progression by inducing inflammatory microenvironment (2012)
  • Author(s): Yoshitaka Kimura, Marimo Sato-Matsushita, Hideaki Tahara, Tatsuro Irimura
  • Organizer: 20th International Symposium on Molecular Cell Biology of Macrophages 2012
  • Place of Presentation: Sanjo Conference Hall, Tokyo
• [Presentation] IL-17-producing NK1.1+ CD27+ T cells promote tumor malignant progression by inducing inflammatory microenvironment (2012)
  • Author(s): Yoshihiro Hayakawa, Yoshitaka Kimura, Naoki Tsunekawa, Marimo Sato-Matsushita, Hideaki Tahara, Ikuo Saiki, Tatsuro Irimura
  • Organizer: 第16回日本がん免疫学会総会
  • Place of Presentation: 北海道大学学術交流センター、札幌
• [Presentation] IL-17-producing NK1.1+ CD27+ T cells promote tumor malignant progression by inducing inflammatory microenvironment (2012)
  • Author(s): 早川 芳弘、佐藤（松下） まりも、田原 秀晃、済木 育夫、入村 達郎
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌、札幌
• [Presentation] IL-17-producing NK1.1+ CD27+ T cells promote tumor malignant progression by inducing inflammatory microenvironment (2012)
  • Author(s): Yoshitaka Kimura, Marimo Sato-Matsushita, Hideaki Tahara, Tatsuro Irimura, Yoshihiro Hayakawa
  • Organizer: 第41回日本免疫学会総会・学術集会
  • Place of Presentation: 神戸国際会議場、神戸
• [Presentation] Evidences for cancer immune-escalation process and the role of inflammatory cytokines (2011)
  • Author(s): Yoshihiro Hayakawa, Marimo Sato-Matsushita, Yoichiro Iwakura, Hideaki Tahara, Tatsuro Irimura
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
• [Presentation] Induction of memory Th1 cell responses with IL-23 produced by human mature dendritic cells stimulated with OK-432 combined with PGE2 (2011)
  • Author(s): Marimo Sato-Matsushita, Hisako Katano and Hideaki Tahara
  • Organizer: 第21回日本樹状細胞研究会
  • Place of Presentation: 福岡