Clinical significance of ghrelin expression in the gastric mucosa of morbidly obese patients

• Project/Area Number: 23791483
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: Osaka University
• Principal Investigator: MIYAZAKI Yasuhiro 大阪大学, 臨床医工学融合研究教育センター, 特任研究員 (00571390)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 代謝栄養外科学 / 胃十二指腸外科学

Research Abstract

In obese patients, the number of GPCs (ghrelin positive cells) was greater than in non-obese patients。 This study showed that the number of GPCs could be a prognostic factor for the surgical results of LSG and represent an individual ghrelin profiles more accurately than circulating ghrelin levels。

Research Products

• [Journal Article] Mapping analysis of ghrelin producing cells in the human stomach associated with chronic gastritis and early cancers (2012)
  • Author(s): Takiguchi S, Adachi S, Yamamoto K, Morii E, Miyata H, Nakajima K, Yamasaki M, Kangawa K, Mori M, Doki Y
  • Journal Title: Dig Dis Sci Volume: 57(5) Pages: 1238-46
• [Journal Article] Clinical trial of ghrelin synthesis administration for upper GI surgery (2012)
  • Author(s): Takiguchi S, Hiura Y, Miyazaki Y, Takata A, Murakami K, Doki Y
  • Journal Title: Methods Enzymol Volume: 514 Pages: 409-31
• [Journal Article] Mapping analysis of ghrelin producing cells in the human stomach associated with chronic gastritis and early cancers. (2012)
  • Author(s): Takiguchi S, et al.
  • Journal Title: Digestive diseases and sciences Volume: 57 Issue: 5 Pages: 1238-1246
  • DOI: 10.1007/s10620-011-1986-2
  • Peer Reviewed
• [Journal Article] Clinical trial of ghrelin synthesis administration for upper GI surgery. (2012)
  • Author(s): Takiguchi S, et al.
  • Journal Title: Methods Enzymol Volume: 514 Pages: 409-431
  • DOI: 10.1016/b978-0-12-381272-8.00026-x
  • Peer Reviewed
• [Presentation] 腹腔鏡下袖状胃切除術における2型糖尿病改善効果とグレリンホルモン (2012)
  • Author(s): 宮崎 安弘 他
  • Organizer: 第67回 日本消化器外科学会総会
  • Year and Date: 2012-07-20
• [Presentation] 腹腔鏡下袖状胃切除術とグレリン (2012)
  • Author(s): 宮崎 安弘 他
  • Organizer: 第30回 日本肥満症治療学会学術集会
  • Year and Date: 2012-06-02
• [Presentation] 腹腔鏡下袖状胃切除術とグレリン
  • Author(s): 宮崎 安弘
  • Organizer: 第30回 日本肥満症治療学会学術集会
  • Place of Presentation: 東京
• [Presentation] 腹腔鏡下袖状胃切除術における２型糖尿病改善効果とグレリンホルモン
  • Author(s): 宮崎 安弘
  • Organizer: 第67回 日本消化器外科学会総会
  • Place of Presentation: 富山