The conquest of anti NeuGc antibody mediated xenogeneic islet rejection through CD47-SIRPα signaling.
| Project/Area Number |
23791484
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
IDE Kentaro 広島大学, 病院, 助教 (50511565)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 異種移植 / B 細胞 / CD47 / B細胞 / SIRPα / ＳＩＲＰα |
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| Research Abstract |
We evaluated the expression of SIRPα on B cell in cytidine monophospho-N-acetylneuraminic acid hydroxylase-deficient mice. There are no SIRPα expressed B cells in the spleen, bone marrow and peripheral blood. However, B cells in the peritoneal cavity only expressed high levels of SIRPα. About 80% of B cells in the peritoneal cavity were B-1 cells. Furthermore, B-1a and B-1b cells expressed high levels of SIRPα. In contrast, B-2 cells did not express the SIRPα.
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Report
(3 results)
Research Products
(15 results)
