| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
We have demonstrated that ex vivohypoxic preconditioning of bone marrow cells from young healthy individuals can enhance their potency for inducing therapeutic angiogenesis. However, considering that advanced aged and systemic disease such as diabetes could contribute to dysfunction of bone marrow cells, the effect of hypoxic pretreatment on these functionally impaired cells is unknown. This study shows that hypoxic preconditioning enhances the angiogenic potency of the bone marrow cells with aged-related functional impairment.
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