Immunological tolerance of donor-specific transfusioninduced by Indoleamine 2,3-dioxygenase (IDO) positive dendritic cells

• Project/Area Number: 23791488
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: The University of Tokushima
• Principal Investigator: IKEMOTO Tetsuya 徳島大学, 大学院・へルスバイオサイエンス研究部, 助教 (20398019)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: Foxp3 / 調節性T細胞 / 免疫寛容 / 移植免疫 / IDO / DST / 実験的膵島移植

Research Abstract

A possible mechanism of donor-specific tolerance by donor-specific transfusion (DST) is to be induced by donor-derived CD11b+cells due to an expansion of regulatory T cells in recipient, this mechanism is considered that recipient Indoleamine 2,3-dioxygenase positive dendritic cells play an important role

Research Products

• [Journal Article] Changes of Immunological parameters with administration of Japanese Kampo medicine (Juzen-Taihoto/TJ-48) in patients with advanced pancreatic cancer. (2013)
  • Author(s): Ikemoto T, Shimada M, Iwahashi S, et al.
  • Journal Title: Int J Clin Oncol
  • Peer Reviewed
• [Journal Article] Indoleamine 2,3-dioxygenase Affects the Aggressiveness of Intraductal Papillary Mucinous Neoplasms Through (2013)
  • Author(s): Ikemoto T et al
  • Journal Title: Pancreas Volume: Jan;42(1) Issue: 1 Pages: 130-134
  • DOI: 10.1097/mpa.0b013e3182575e4a
  • Peer Reviewed
• [Journal Article] Changes of immunological parameters with administration of Japanese Kampo medicine (Juzen-Taihoto/TJ-48) in patients with advanced pancreatic cancer. (2013)
  • Author(s): Ikemoto T et al
  • Journal Title: Int J Clin Oncol. Volume: Feb 27
• [Journal Article] Indoleamine 2,3-dioxygenase Affects the Aggressiveness of Intraductal Papillary Mucinous Neoplasms Through Foxp3+CD4+CD25+ T Cells in Peripheral Blood. (2012)
  • Author(s): Ikemoto T, Shimada M, Komatsu M,et al.
  • Journal Title: Pancreas
  • Peer Reviewed
• [Journal Article] Japanese Herbal Medicine TJ-48 prevents autoimmune diabetes in NOD mice. (2011)
  • Author(s): Ikemoto T.
  • Journal Title: Am J Chin Med. Volume: 394（ 4） Pages: 743-756
  • Peer Reviewed
• [Presentation] Jagged 1/Notch発現とIndolamine 2,3-deoxygenase（IDO）陽性樹状細胞によって誘導される調節性T細胞のIPMN悪性度反映に関する検討 (2012)
  • Author(s): 池本哲也 他
  • Organizer: 第67回 日本消化器外科学会総会
  • Place of Presentation: 富山国際会議場（富山）
• [Presentation] Impact of dendritic cell-induced regulatory T cell as a possible novel biomarker for surgical indication of IPMN (2012)
  • Author(s): Ikemoto T et al
  • Organizer: 22nd World Congress of the International Association of Surgeon,Gastroenterlogists and Oncologists
  • Place of Presentation: Shangri-la Hotel（Thailand）
• [Presentation] 各臓器移植における免疫寛容 IFN inducible IDO+形質細胞様樹状細胞による免疫寛容誘導 (2011)
  • Author(s): 池本哲也、島田光生 他
  • Organizer: 第47回日本移植学会
  • Place of Presentation: 仙台国際センター(宮城県)
  • Year and Date: 2011-10-04
• [Presentation] The role of donor specific regulatory T cells expanded by interferon-gamma inducible indoleamine 2, 3-dioxygenase (IDO) + plasmacytoid dendritic cell (2011)
  • Author(s): Ikemoto T, et al.
  • Organizer: 12th Congress of the Asian Society of Transplantation
  • Place of Presentation: COEX(韓国)
  • Year and Date: 2011-09-25
• [Presentation] IFN inducible IDO+形質細胞様樹状細胞による免疫寛容誘導
  • Author(s): 池本哲也
  • Organizer: 第47回日本移植学会
  • Place of Presentation: 仙台（仙台国際センター）