| Project/Area Number |
23791489
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
|
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 肝臓外科学 / 肝細胞移植 / 脂肪性肝炎 / アポトーシス / 再生医療 |
|---|
| Research Abstract |
In recently, surgical management of hepatocellular carcinoma should be addressed for non-viral hepatitis and liver cirrhosis. We attempt to apply liver replacement therapy using hepatocyte transplantation for clinical therapy. In order to achieve it, we developed rat liver replacement model which imitated clinical human NASH/NAFLD. In this model, we revealed a cell physiology of the transplanted cells which generated bile duct linage cells. In addition, we succeded to increase survival rate in NASH liver cirrhotic model. In the clinical research, we reported a benefit and default of donor cell procurement. We also revealed that a clinical value of BTR, ATIII, and GSA. We classified various liver functional indicators using clustering analysis.
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