| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
To elucidate the molecular mechanism of hepatic tumorigenesis, which is considered to related to the self-renewal of hepatic stem/progenitor cell, we attempted to identify the downstream target genes of Polycomb group protein Ring1 that is essential for self-renewal of hepatic stem cells. By microarray and ChIP-PCR analysis, we extracted Cdkn2a as a Ring1B target gene. We investigated the expansion of hepatic stem/progenitor cell during hepatogenesis in cdkn2a and ring1B deficient mice, the result showed that the rescue is limited. We concluded that Ring1B should have other important downstream targets in addition to Cdkn2a in stem/progenitor cells.
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