| Project/Area Number |
23791491
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
|
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
NAKATA Susumu 愛知県がんセンター(研究所), 腫瘍病理学部, 主任研究員 (80590695)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | ヒストン修飾 / 肝幹細胞 / 肝細胞分化 / 肝細胞癌 / 遺伝子発現 / エピジェネティクス |
|---|
| Research Abstract |
We found some histone modifications that change its localization and amount between embryonic hepatic stem cells and adult hepatocytes. We identified their target genes at genomic level, demonstrating vast majority of the targets of a repressive histone mark, H3K27me3, are mutually exclusive. An integrated analysis revealed that some functional genes involved in metabolisms were repressed by H3K27me3 and that some early development-related and cell cycle-promoting genes were associated with distinct transcription activating pattern of the histone marks in the hepatic stem cells.
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