| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
As the native liver of biliary atresia patients is cirrhotic and the long-term survival rate of such patients with their native liver is low, coupled with the fact that extremely short telomeres are associated with subsequent carcinogenesis and organ failure, it can be said that prominent telomere shortening in the hepatic tissue of biliary atresia patients in comparison with normal controls supports the early implementation of liver transplantation, regardless of the degree of liver cirrhosis.
Telomere length analysis using quantitative fluorescence in situ hybridization could be an objective indicator of hepatocellular reserve capacity in patients with biliary atresia, and excessive telomere shortening supports the early implementation of liver transplantation.
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