Analysis of cancer stem cell properties andepithelial-mesenchymal transition signals in recurrence and metastasis of breast cancer cells
| Project/Area Number |
23791496
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | Keio University |
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Principal Investigator |
ARIMA Yoshimi 慶應義塾大学, 医学部, 助教 (20309751)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 癌 / 再発 / 転移 / EMT / 乳癌幹細胞 |
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| Research Abstract |
We determined that Rb inactivation induces epithelial-mesenchymal transition, EMT through the ZEB expression. We conducted ZEB1 inhibitor screening and identified several chemical inhibitors of the ZEB1protein expression, which included CDK inhibitors. Th
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Induction of ZEB Proteins by Inactivation of RB Protein Is Key Determinant of Mesenchymal Phenotype of Breast Cancer.2012
Author(s)
Arima Y,Hayashi H, Sasaki M, Hosonaga M, Goto TM, Chiyoda T, Kuninaka S, Shibata T, Ohata H, Nakagama H, Taya Y, Saya H
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Journal Title
J Biol Chem
Volume: 287
Pages: 7896-906
Related Report
Peer Reviewed
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[Journal Article] Induction of ZEB Proteins by Inactivation of RB Protein Is Key Determinant of Mesenchymal Phenotype of Breast Cancer.2012
Author(s)
Arima Y, Hayashi H, Sasaki M, Hosonaga M, Goto TM, Chiyoda T, Kuninaka S, Shibata T, Ohata H, Nakagama H, Taya Y, Saya H.
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Journal Title
J Biol Chem.
Volume: 287(11)
Pages: 7896-7906
Related Report
Peer Reviewed
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