Analysis of cancer stem cell properties andepithelial-mesenchymal transition signals in recurrence and metastasis of breast cancer cells

• Project/Area Number: 23791496
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: Keio University
• Principal Investigator: ARIMA Yoshimi 慶應義塾大学, 医学部, 助教 (20309751)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 癌 / 再発 / 転移 / EMT / 乳癌幹細胞

Research Abstract

We determined that Rb inactivation induces epithelial-mesenchymal transition, EMT through the ZEB expression. We conducted ZEB1 inhibitor screening and identified several chemical inhibitors of the ZEB1protein expression, which included CDK inhibitors. Th

Research Products

• [Journal Article] Induction of ZEB Proteins by Inactivation of RB Protein Is Key Determinant of Mesenchymal Phenotype of Breast Cancer. (2012)
  • Author(s): Arima Y,Hayashi H, Sasaki M, Hosonaga M, Goto TM, Chiyoda T, Kuninaka S, Shibata T, Ohata H, Nakagama H, Taya Y, Saya H
  • Journal Title: J Biol Chem Volume: 287 Pages: 7896-906
  • Peer Reviewed
• [Journal Article] Loss of p16 expression is associated with the stem cell characteristics of surface markers and therapeutic resistance in estrogen receptor-negative breast cancer (2012)
  • Author(s): Arima Y, Hayashi N, Hayashi H, Sasaki M,Kai K, Abe E, Yoshida A, Mikami S, Nakamura S, and Saya H
  • Journal Title: Int J Cancer Volume: 130 Pages: 2568-79
  • Peer Reviewed
• [Journal Article] Loss of p16 expression is associated with the stem cell characteristics of surface markers and therapeutic resistance in estrogen receptor-negative breast cancer (2012)
  • Author(s): Arima Y, Saya H, et al
  • Journal Title: InternationalJournal of Cancer Volume: 130 Issue: 11 Pages: 2568-2579
  • DOI: 10.1002/ijc.26271
  • Peer Reviewed
• [Journal Article] Induction of ZEB Proteins by Inactivation of RB Protein Is Key Determinant of Mesenchymal Phenotype of Breast Cancer. (2012)
  • Author(s): Arima Y, Hayashi H, Sasaki M, Hosonaga M, Goto TM, Chiyoda T, Kuninaka S, Shibata T, Ohata H, Nakagama H, Taya Y, Saya H.
  • Journal Title: J Biol Chem. Volume: 287(11) Pages: 7896-7906
  • Peer Reviewed
• [Presentation] The role of CDK4/6 in cancer cells and the potential therapeutic effects of CDK4/6 inhibitors (2012)
  • Author(s): Arima Yand Saya H
  • Organizer: The 17th Japan-Korea Cancer Research Workshop
  • Place of Presentation: Busan, Korea
• [Presentation] The role of CDK4/6 in cancer cells and the potential therapeutic effects of CDK4/6 inhibitors. (2012)
  • Author(s): Arima Y, Hosonaga M, Sugihara E and Saya H
  • Organizer: 2012 Annual Meeting of the American Society for Cell Biology
  • Place of Presentation: San Francisco,CA, USA
• [Presentation] The role of CDK4/6 in cancer cells and the potential therapeutic effects of CDK4/6 inhibitors. (2012)
  • Author(s): Yoshimi Arima
  • Organizer: The 17th Japan-Korea Cancer Research Workshop
  • Place of Presentation: Busan, Korea
• [Remarks] 慶應義塾大学・医学部・先端研遺伝子制御
  • URL: http://www.genereg.jp/
• [Remarks] 慶應義塾大学医学部先端研遺伝子制御研究部門
  • URL: http://www.genereg.jp/
• [Remarks]
  • URL: http://www.genereg.jp/