Drug sensitivity of PLK1-overexpressing cancer

• Project/Area Number: 23791503
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: St. Marianna University School of Medicine
• Principal Investigator: SATO Ko 聖マリアンナ医科大学, 医学(系)研究科(研究院), 助教 (30598462)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: PLK1 / BRCA1 / drug sensitivity / PLK1: Cambridge, UK / Anticancer drugs Madrid

Research Abstract

PLK1-overexpressing cancers are sensitive to Camptothecin and PARP inhibitor, but not to Mitomycin C.

Research Products

• [Journal Article] Venkitaraman AR. A DNA-Damage Selective Role for BRCA1 E3 ligase in Claspin Ubiquitylation, CHK1 activation, and DNA repair. (2012)
  • Author(s): Sato K, Sundaramoorthy E, Rajendra E, Hattori H, Jeyasekharan AD, Ayoub N, Schiess R, Aebersold R, Nishikawa H, Sedukhina AS, Wada H, Ohta T
  • Journal Title: Curr. Biol Volume: 22 Pages: 1659-66
• [Presentation] Overexpression of PLK1 sensitisesce llsto Camptothecin and PARP inhibitor,butnotto (2013)
  • Author(s): Ko Sato
  • Organizer: MitomycinC、collaborationmeetingat CNIC,Spain
  • Place of Presentation: Madrid,Spain
• [Presentation] Overexpression of PLK1 sensitises cells to Camptothecin and PARP inhibitor, but not to Mitomycin C (2013)
  • Author(s): Ko Sato
  • Organizer: collaboration meeting at CNIC, Spain
  • Place of Presentation: Madrid, Spain
  • Invited