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The roles of novel MHC receptors, MMRs, in molecular mechanism of allograft rejection

Research Project

Project/Area Number 23791505
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General surgery
Research InstitutionKansai University of Welfare Sciences (2014-2015)
Osaka Medical College (2011-2013)

Principal Investigator

Tashiro-Yamaji Junko  関西福祉科学大学, 健康福祉学部, 准教授 (40340559)

Research Collaborator Yamana Hidenori  大阪医科大学, 消化器外科学, 大学院生
Maeda Shogo  大阪医科大学, 形成外科学, 大学院生
Project Period (FY) 2011-04-28 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords移植免疫 / 同種異系移植 / 自然免疫 / 移植・再生医療 / 免疫学 / 遺伝子 / 細胞・組織 / 生体分子
Outline of Final Research Achievements

Recently, we have isolated two novel receptors for allogeneic MHCs on macrophages/monocytes, Macrophage MHC receptor1 (MMR1) and MMR 2. In this study, we examined the physiological roles of MMR1 and MMR2. Study using generation of MMR2 knockout (KO) mice on a C57BL/6 background or binding assay with MHC molecules demonstrated that MMR1 and 2 were bound to 1 to 3 allogeneic MHC class I molecules and that MMR1 and 2 on monocytes/macrophages in mice were essential for recognition and rejection of allografted skin.

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (19 results)

All 2016 2015 2014 2013 2012 2011 Other

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (12 results) Remarks (1 results)

  • [Journal Article] Blood supply-susceptible formation of melanin pigment in hair bulb melanocytes of mice.2015

    • Author(s)
      Maeda S, Ueda K, Yamana H, Tashiro-Yamaji J, Ibata M, Mikura A, Okada M, Yasuda E, Shibayama Y, Yoshino M, Kubota T, Yoshida R.
    • Journal Title

      Plast Reconstr Surg Glob Open

      Volume: e328 Issue: 3 Pages: 1-9

    • DOI

      10.1097/gox.0000000000000284

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Down-regulated expression of monocyte/macrophage major histocompatibility complex receptors in human and mouse monocytes by expression of their ligands.2014

    • Author(s)
      Yamana H, Tashiro-Yamaji J, Hayashi M, Maeda S, Shimizu T, Tanigawa N, Uchiyama K, Kubota T, Yoshida R.
    • Journal Title

      Clin Exp Immunol.

      Volume: 178 Issue: 1 Pages: 118-128

    • DOI

      10.1111/cei.12383

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Macrophage MHC and T-cell receptors essential for rejection of allografted skin and lymphoma.2013

    • Author(s)
      Tashiro-Yamaji J, Maeda S, Ikawa M, Okabe M, Kubota T, and Yoshida R
    • Journal Title

      Transplantation

      Volume: 96 (3) Issue: 3 Pages: 251-257

    • DOI

      10.1097/tp.0b013e3182985527

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Specific binding of HLA-B44 to human macrophage MHC receptor 1 on monocytes.2012

    • Author(s)
      Tashiro-Yamaji J, Shimizu T, Hayashi M, Yamana H, Tanigawa N, Uchiyama K, Kubota T, Yoshida R.
    • Journal Title

      Gene

      Volume: 501 (2) Pages: 127-34

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transgene Number-dependent, Gene Expression Rate-independent Rejection of Dd-, Kd-, or DdKd-Transgened Mouse Skin or Tumor Cells from C57BL/6 (DbKb) Mice.2011

    • Author(s)
      Inoue Y, Tashiro-Yamaji J, Hayashi M, Kiyonari H, Shimizu T, Ibata M, Yamana H, Kubota T, Tanigawa N, Yoshida R.
    • Journal Title

      Microbiology and Immunology

      Volume: 55 Issue: 6 Pages: 446-453

    • DOI

      10.1111/j.1348-0421.2011.00337.x

    • NAID

      10031121489

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Isolation and characterization of a cDNA encoding a novel human receptor homologous to mouse macrophage major histocompatibility complex (MHC) receptor(MMR)12011

    • Author(s)
      Junko Tashiro-Yamaji, Tetsunosuke Shimizu, Hidenori Yamana, Wakako Miyachi, Keiko Hasegawa, Yukako Shiraiwa, Yoshiaki Mori, Ryotaro Yoshida, and Takahiro Kubota.
    • Journal Title

      J Physiological Sciences

      Volume: 61(1)

    • Related Report
      2011 Research-status Report
  • [Presentation] Role of unsaturated fatty acids on expression of myosin heavy chain type II b mRNA in mouse myocytes.2016

    • Author(s)
      Junko Yamaji et al.
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      北海道、札幌市
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Enhancement of myosin heavy chain class I (MHC I) mRNA expression in C2C12 myocyte by multivalent cations2015

    • Author(s)
      Mori Y., Yamaji J., Hiroshima R., et al.
    • Organizer
      第120回日本解剖学会総会全国学術大会・第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸コンベンションセンター(神戸国際会議場・神戸国際展示場)(兵庫県神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Enhancement of myosin heavy chain class I (MyHC I) mRNA expression in C2C12 myocyte by chlorogenic acid2014

    • Author(s)
      Yamaji J., et al.
    • Organizer
      WMS2014
    • Place of Presentation
      Thaersaal, Humboldt university(Berlin)
    • Year and Date
      2014-10-08
    • Related Report
      2014 Research-status Report
  • [Presentation] Essential role of Macrophage MHC receptor (MMR) in allograft rejection: generation and analysis of MMR2 knockout mice2014

    • Author(s)
      Tashiro-Yamaji J, Maeda S, Ikawa M, Okabe M, Daikoku E, Saito M, Shiraiwa Y, Yoshida R, and Kubota T.
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島県鹿児島市 鹿児島大学郡元キャンパス
    • Related Report
      2013 Research-status Report
  • [Presentation] The role of Macrophage MHC receptor (MMR)1 in allorecognition: Isolation of a cDNA encoding a novel MHC receptor for HLA-B44, human MMR12013

    • Author(s)
      Tashiro-Yamaji J, Shimizu T, Daikoku E, Saito M, Shiraiwa Y, Yoshida R, and Kubota T.
    • Organizer
      37th Congress of the International Union of Physiological Sciences (IUPS2013)
    • Place of Presentation
      イギリス、バーミンガム
    • Related Report
      2013 Research-status Report
  • [Presentation] Establishment and analysis of MMR2 knockout mice: the role of Macrophage MHC receptor (MMR) 1 and 2 in allograft rejection2013

    • Author(s)
      Junko Tashiro-Yamaji, Shogo Maeda, Masahito Ikawa, Masaru Okabe, Hidenori Yamana, Natsuki Hannya, Masahisa Saito, Eriko Daikoku, Yuka Shiraiwa, Ryotaro Yoshida, and Takahiro Kubota.
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京都江戸川区
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒト単球/マクロファージMHC受容体(MMR)によるHLAの識別2012

    • Author(s)
      山路-田代純子、清水徹之介、山名秀典、前田尚吾、般若夏樹、窪田隆裕、吉田龍太郎
    • Organizer
      第23回日本生体防御学会学術総会
    • Place of Presentation
      東京都・品川区
    • Related Report
      2012 Research-status Report
  • [Presentation] The roles of Monocyte/Macrophage MHC receptors (MMRs) in allograft rejection: the generation of MMR2 deficient mice2012

    • Author(s)
      TASHIRO-YAMAJI Junko, MAEDA Shogo, IKAWA Masahito, OKABE Masaru, INOUE Yoshihiro, SHIMIZU Tetsunosuke, YAMANA Hidenori, HANNYA Natsuki, KUBOTA Takahiro, YOSHIDA Ryotaro.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      兵庫県・神戸市
    • Related Report
      2012 Research-status Report
  • [Presentation] Specific binding of HLA-A32, -B13 and -B62 molecules to human monocyte/macrophage MHC receptor 2 on monocytes2012

    • Author(s)
      YAMANA Hidenori, TASHIRO-YAMAJI Junko, SHIMIZU Tetsunosuke, HAYASHI Michihiro, TANIGAWA Nobuhiko, UCHIYAMA Kazuhisa, KUBOTA Takahiro, YOSHIDA Ryotaro.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      兵庫県・神戸市
    • Related Report
      2012 Research-status Report
  • [Presentation] Isolation of a human cDNA homologous to a mouse cDNA encoding a receptor for allogeneic MHC (H-2Dd) [macrophage MHC receptor 1 (MMR1)]2012

    • Author(s)
      Junko Tashiro-Yamaji, Tetsunosuke Shimizu, Hidenori Yamana, Shogo Maeda, Natsuki Hannnya, Masahisa Saito, Eriko Daikoku, Yuka Shiraiwa, Ryotaro Yoshida, and Takahiro Kubota.
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本市・信州大 松本キャンパス、松本市文化会館、松本市総合体育館
    • Related Report
      2011 Research-status Report
  • [Presentation] マウスマクロファージMHC受容体(MMR)1・2 の非自己(同種異系)識別機構の解析2011

    • Author(s)
      山路 純子(田代 純子)、清水徹之介、山名秀典、前田尚吾、般若夏樹、大黒恵理子、齊藤昌久、森 禎章、白岩有桂、吉田龍太郎、窪田隆裕
    • Organizer
      日本生理学会 第104回近畿生理談話会
    • Place of Presentation
      大阪医科大学
    • Related Report
      2011 Research-status Report
  • [Presentation] Characterization of a novel human receptor homologous to mouse macrophage major histocompatibility complex (MHC) receptor(MMR)12011

    • Author(s)
      Junko Tashiro-Yamaji, Tetsunosuke Shimizu, Hidenori Yamana, Shogo Maeda, Natsuki Hannya, Takahiro Kubota, and Ryotaro Yoshida.
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉市・幕張メッセ
    • Related Report
      2011 Research-status Report
  • [Remarks] J Physiological Sciences誌による研究発表は、東北大震災の影響により、J Physiological Sciences誌上開催に切り替えられた第88回日本生理学会大会 第116回日本解剖学会総会・全国学術集会合同大会(予定開催地:横浜市・パシフィコ横浜)における研究内容を示す。

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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