| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) is a standard operation for patients with "Ulcerative colitis (UC)" and "Familial adenomatous polyposis (FAP)". Pouchitis is a major complication after IPAA, which pathogenesis is unknown. The aim of this study is to evaluate (1) the time-dependent change of the gene expression at the pouch mucosa after IPAA, (2) the differences of gene expressions between colonic mucosa and small intestinal mucosa, and (3) the difference of gene expressions between "ileal interposition" mouse and sham mouse.
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